Choose your country to see the products for your location

P040 CLL

SALSA® MLPA® Probemix P040 CLL detects copy number variations in the TP53 gene, the RB1/DLEU/MIR15A-16-region, the ATM gene and detects the presence of trisomy 12.

Specifications

Contents: 52 MLPA probes, including 6 probes for TP53, 10 probes for the RB1/DLEU/MIR15A-16-region, 12 probes for chromosome 11 of which 7 probes for ATM, and 11 probes for chromosome 12.

Tissue: human genomic DNA, including DNA from paraffin-embedded tissues.

Application: research on B-cell chronic lymphocytic leukemia.

For research use only (RUO). Not for use in diagnostics.

Quick links

List Prices Documentation

Key related products

P037 CLL-1

Contains probes for 2p, 6q, 8p/q, 9p21, ATM, chromosome 12, 13q14 and TP53.

P038 CLL-2

Contains probes for 11q, 12p/q, 13q14, TP53 & PTEN genes and probes specific for NOTCH1 p.P2514*fs, SF3B1 p.K700E and MYD88 p.L265P point mutations.

P041 ATM-1

Contain probes for all ATM exons.

View all

General information

The SALSA MLPA Probemix P040 CLL is a research use only (RUO) assay for the detection of deletions or duplications in the TP53 gene on 17p13, the RB1/DLEU/MIR15A-16-region on 13q14, the ATM gene on 11q22 as well the presence of trisomy 12 in DNA samples obtained from chronic lymphocytic leukemia patients.

B cell chronic lymphocytic leukemia (B-CLL) is the most common hematologic neoplasm in Western countries and results in the progressive accumulation of morphologically mature but functionally incompetent CD5(+) CD23(+) B lymphocytes in bone marrow, blood, spleen and lymph nodes of the affected person. Chromosomal translocations are rare events in B-CLL. Copy number changes of certain chromosomal regions are however frequent. Some of these have been found to be prognostic markers of this disease.

SALSA MLPA probemixes P037 and P038 contain probes for several genomic regions and genes that are recurrently imbalanced in B-CLL. This P040 probemix contains a selection of targeted genes and regions from P037 and P038.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK470433/

Regulatory status

SALSA MLPA Probemix P040 CLL is for research use only (RUO) in all territories.

Product documentation

Version B2

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P040-025R
SALSA MLPA Probemix P040 CLL – 25 rxn
MLPA
€ 286.00
P040-050R
SALSA MLPA Probemix P040 CLL – 50 rxn
MLPA
€ 560.00
P040-100R
SALSA MLPA Probemix P040 CLL – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-Cy5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-Cy5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

See this support article for commercially available positive samples that have been tested with this product.

Resources

General MLPA resources

MLPA education

This site uses cookies to help improve your online experience. Learn more
No, thank you accept

Sign in

Don't have an account? Create one

Forgot password?

Select Your Country

Choose your country to see the products for your location