In the Spotlight
Introducing SALSA digitalMLPA, the latest innovation from MRC Holland
SALSA digitalMLPA is a revolution in copy number variation (CNV) detection. digitalMLPA builds off the robust MLPA technology and employs the power of Illumina next generation sequencing platforms for data generation. This new technology offers an impressive scaleup in CNV detection with the inclusion of up to 1000 probes in a single reaction on just 20 ng of DNA.
MC002 SMA Newborn Screen: study finds 100% sensitivity & specificity on DBS cards of SMA patients
A clinical performance study by Isala and two other labs using SALSA MC002 SMA Newborn Screen on anonymised dried blood spot (DBS) cards of 47 SMA patients and 375 controls found a 100% diagnostic sensitivity and specificity.
Reduced sloping with the new MLPA buffer
Starting March 2019, all shipments of SALSA MLPA Reagent Kits will include a modified SALSA MLPA Buffer. There will also be a small change in the storage buffer of the SALSA Ligase-65 enzyme. The new reagents strongly reduce peak pattern sloping that is frequently observed when DNA is extracted with a magnetic beads-based system.
