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SALSA digitalMLPA is a revolution in copy number variation (CNV) detection. digitalMLPA builds off the robust MLPA technology and employs the power of Illumina next generation sequencing platforms for data generation. This new technology offers an impressive scaleup in CNV detection with the inclusion of up to 1000 probes in a single reaction on just 20 ng of DNA.
A clinical performance study by Isala and two other labs using SALSA MC002 SMA Newborn Screen on anonymised dried blood spot (DBS) cards of 47 SMA patients and 375 controls found a 100% diagnostic sensitivity and specificity.
Starting March 2019, all shipments of SALSA MLPA Reagent Kits will include a modified SALSA MLPA Buffer. There will also be a small change in the storage buffer of the SALSA Ligase-65 enzyme. The new reagents strongly reduce peak pattern sloping that is frequently observed when DNA is extracted with a magnetic beads-based system.
Due to Brexit and the current uncertainty in trade agreements between the UK and EU there will be a pause in shipping to the UK from 1–18 January 2021. For shipment to the UK this year, orders must be received before 15 December 2020.
MRC Holland will be closed from 25 December 2020 until 1 January 2021. When planning your orders, please keep the following dates in mind:
Last shipping date 2020: Monday 21 December; order deadline: Monday 7 December 2020.
First shipping date 2021: Tuesday 05 January; order deadline: Sunday 20 December 2020.
MRC Holland’s SALSA® MLPA Probemix ME011 Mismatch Repair Genes is the first methylation-specific (MS) MLPA probemix to be CE-marked for in vitro diagnostic use in Europe.
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