MRC Holland - MRC Holland

The importance of copy numbers in genetic diagnostics and research

Copy number variants play a role in many genetic disorders. The fast, accurate and affordable detection of CNVs is essential for clinical genetic testing and research.

MRC Holland develops tools for the detection of DNA copy numbers and methylation patterns associated with disease. Our MLPA^® technique is the gold standard in this field, and is used around the world to study hereditary disorders and tumours.

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Latest News

Mar 31, 2025

MLPA and digitalMLPA in Pediatric Acute Lymphoblastic Leukemia

A study published in Modern Pathology by researchers from Semmelweis University (Budapest, Hungary), in collaboration with scientists from MRC Holland, utilised MLPA and digitalMLPA in combination with DNA and RNA sequencing to extensively characterise a nationwide cohort of 192 pediatric acute lymphoblastic leukemia (ALL) patients.
Mar 20, 2025

Coffalyser.Net - License Renewal or Update - User Action May Be Required

Action may be required from users of Coffalyser.Net, our free analysis software. Users of the latest version of Coffalyser.Net (v.250317.1029) do not need to perform any action. Users of v.240129.1959 are required to renew their license which is easy to do and free of charge. Users of older versions of Coffalyser.Net are required to update to version v.240129.1959 or v.250317.1029. This is required for users making use of both preconfigured, as well as custom SQL Servers.
Mar 03, 2025

Our Products are IVDR-Certified!

We have successfully obtained our certification under the new In Vitro Diagnostic Regulation (IVDR; 2017/746)! The first batch of flagship products are already available on the market under the new IVDR, well in advance of the transition period deadline.