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MRC Holland: Confidence in Copy Number Determination

The importance of copy numbers in genetic diagnostics and research

Copy number variants play a role in many genetic disorders. The fast, accurate and affordable detection of CNVs is essential for clinical genetic testing and research.

MRC Holland develops tools for the detection of DNA copy numbers and methylation patterns associated with disease. Our MLPA technique is the gold standard in this field, and is used around the world to study hereditary disorders and tumours.

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Latest News

  • Dec 02, 2020

    Temporary pause in UK shipping

    Due to Brexit and the current uncertainty in trade agreements between the UK and EU there will be a pause in shipping to the UK from 1–18 January 2021. For shipment to the UK this year, orders must be received before 15 December 2020.

  • Nov 24, 2020

    MRC Holland holiday closure

    MRC Holland will be closed from 25 December 2020 until 1 January 2021. When planning your orders, please keep the following dates in mind:

    Last shipping date 2020: Monday 21 December; order deadline: Monday 7 December 2020.

    First shipping date 2021: Tuesday 05 January; order deadline: Sunday 20 December 2020.

  • Nov 06, 2020

    First MS-MLPA assay CE-marked: ME011 Mismatch Repair Genes

    MRC Holland’s SALSA® MLPA Probemix ME011 Mismatch Repair Genes is the first methylation-specific (MS) MLPA probemix to be CE-marked for in vitro diagnostic use in Europe.

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New & Improved Products

Improved Feb 05, 2021

SALSA MLPA Probemix P439 COL4A3

General information The SALSA MLPA Probemix P439 COL4A3 is a research use only (RUO) assay for the detection of deletions or duplications in the COL4A3 gene, ...

Improved Jan 27, 2021

SALSA MLPA Probemix ME034 Multi-locus Imprinting

General information The SALSA MS-MLPA Probemix ME034 Multi-locus Imprinting is a research use only (RUO) assay for the detection of aberrant methylation of one or more ...

Improved Jan 15, 2021

SALSA MLPA Probemix P329 CRLF2-CSF2RA-IL3RA

General information The SALSA MLPA Probemix P329 CRLF2-CSF2RA-IL3RA is a research use only (RUO) assay for the detection of deletions or duplications in the CRLF2, CSF2RA ...

Improved Jan 12, 2021

SALSA MLPA Probemix P326 LARGE1

General information The SALSA MLPA Probemix P326 LARGE1 is a research use only (RUO) assay for the detection of deletions or duplications in the LARGE1, FKTN ...

New Dec 22, 2020

SALSA MLPA Probemix P481 PRKAR1A-ARMC5

General information The SALSA MLPA Probemix P481 PRKAR1A-ARMC5 is a research use only (RUO) assay for the detection of deletions or duplications in the PRKAR1A and ...

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Improvements

Several target and reference probes were replaced and some probes changed in length.

Improvements

7 new target probes added, 3 reference probes and 1 digestion control probe replaced.

Improvements

One IL3RA probe and one flanking probe have been removed, and one flanking probe replaced.

Improvements

Five target probes have been replaced or added, and four reference probes have been replaced.

New Product

First released on Dec 22, 2020