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MRC Holland: Confidence in Copy Number Determination

The importance of copy numbers in genetic diagnostics and research

Copy number variants play a role in many genetic disorders. The fast, accurate and affordable detection of CNVs is essential for clinical genetic testing and research.

MRC Holland develops tools for the detection of DNA copy numbers and methylation patterns associated with disease. Our MLPA® technique is the gold standard in this field, and is used around the world to study hereditary disorders and tumours.

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New & Improved Products

New Sep 23, 2021

SALSA MLPA Probemix P483 HER gene family

General information The SALSA MLPA Probemix P483 HER gene family is a research use only (RUO) assay for the detection of deletions or duplications in the ...

Improved Sep 07, 2021

SALSA MLPA Probemix P352 PKD1-PKD2

Intended purpose The SALSA MLPA Probemixes P351 PKD1 and P352 PKD1-PKD2 are in vitro diagnostic (IVD)1 or research use only (RUO) semi-quantitative assays2 for the detection ...

Improved Sep 07, 2021

SALSA MLPA Probemix P351 PKD1

Intended purpose The SALSA MLPA Probemixes P351 PKD1 and P352 PKD1-PKD2 are in vitro diagnostic (IVD)1 or research use only (RUO) semi-quantitative assays2 for the detection ...

Improved Aug 16, 2021

SALSA MLPA Probemix P181 Centromere mix 1

General information The SALSA MLPA Probemix P181 Centromere mix 1 is a research use only (RUO) assay for the detection of deletions or duplications in genes ...

Improved Aug 09, 2021

SALSA MLPA Probemix P147 1p36

General information The SALSA MLPA Probemix P147 1p36 is a research use only (RUO) assay for the detection of deletions or duplications in the 1p36 subtelomeric ...

New Jul 29, 2021

SALSA MLPA Probemix P494 NBN

General information The SALSA MLPA Probemix P494 NBN is a research use only (RUO) assay for the detection of deletions or duplications in the NBN gene, ...

New Jul 27, 2021

SALSA MLPA Probemix P492 POLD1 - POLE

General information The SALSA MLPA Probemix P492 POLD1 - POLE is a research use only (RUO) assay for the detection of deletions or duplications in the ...

Improved Jul 21, 2021

SALSA MLPA Probemix ME028 Prader-Willi/Angelman

Intended purpose The SALSA MS-MLPA Probemix ME028 Prader-Willi/Angelman is an in vitro diagnostic (IVD)1 or research use only (RUO) semi-quantitative assay2 for the detection of copy ...

Improved Jul 15, 2021

SALSA MLPA Probemix P138 SLC2A1-STXBP1

Intended purpose The SALSA MLPA Probemix P138 SLC2A1-STXBP1 is an in vitro diagnostic (IVD)1 or research use only (RUO) semi-quantitative assay2 for (1) the detection of ...

Improved Jul 02, 2021

SALSA MLPA Probemix P395 MEF2C-FOXG1

General information The SALSA MLPA Probemix P395 MEF2C-FOXG1 is a research use only (RUO) assay for the detection of deletions or duplications in the MEF2C and ...

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New Product

First released on Sep 23, 2021

Improvements

Three PKD1 probes and one PKD2 probe added. One PKD2 probe and one reference probe replaced.

Improvements

Two PKD1 probes added and two replaced. One TSC2 probe and four reference probes replaced.

Improvements

Four probes changed in length but not in sequence detected and 19 probes were replaced.

Improvements

Seven target probes replaced, nine reference probes replaced and one reference probe added. Two targ

New Product

First released on Jul 29, 2021

New Product

First released on Jul 27, 2021

Improvements

Two SNRPN M-probes added, one digestion control and one reference probe replaced.

Improvements

Four reference probes have been replaced and one removed. One target probe has been added for STXBP1

Improvements

Some target and reference probes replaced. Two target probes added, four probes changed in length.