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Our Technologies: Tools to Simplify Your Copy Number Needs


SALSA® MLPA® is the gold standard for the quantification of copy numbers. Up to 60 different genomic DNA sequences can be quantified simultaneously.

MLPA products are used worldwide to study hereditary disorders, tumour profiling and methylation status in diagnostic and research. With over 350 targeted assays on the market, there is always one that meets your needs.

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The next step in MLPA technology, where an Illumina NGS platform is used for probe sequencing and subsequent count-based probe amplicon quantification.

With SALSA® digitalMLPA™, up to 1000 different genomic DNA sequences can be quantified simultaneously. This enables broad, unparalleled copy number certainty in one simple reaction.

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SALSA Melt Assays

SALSA® Melt Assays are based on high-resolution melt curve analysis, and are a fast and affordable way to identify specific allelic variants that may be associated with disease.

At present we have one Melt Assay: SALSA MC002 SMA Newborn Screen. This assay can reliably identify 95-98% of SMA patients.

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SALSA Melt Assays.

Coffalyser.Net: MLPA analysis software

Coffalyser.Net™ is free MLPA analysis software made and supported by MRC Holland. Coffalyser.Net can directly import raw data files and performs advanced quality checks to increase the robustness of your MLPA results. Analysis sheets for each product can be retrieved directly from our servers, ensuring you always have access to the latest versions.

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Coffalyser digitalMLPA: digitalMLPA analysis software

Coffalyser digitalMLPA™ is free software developed by MRC Holland for the analysis of digitalMLPA data. Coffalyser digitalMLPA automatically recognises digitalMLPA sequence reads from FASTQ files and directly uses them for analysis. Coffalyser digitalMLPA then outputs two clear reports for every sample of your experiment indicating both the quality of the run and the aberrations found.

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Coffalyser digitalMLPA.

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