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SALSA MLPA Probemix P037 CLL-1 detects copy number variations in various genes and regions implicated in B-cell chronic lymphocytic leukemia (B-CLL).
Contents: 54 MLPA probes, including 41 probes for the 2p, 6q, 8p/q, 9p21, 11q, 12p/q, 13q and 17p chromosomal regions.
Tissue: human genomic DNA, including DNA from FFPE tissue.
Application: research on B-cell chronic lymphocytic leukemia (B-CLL).
For research use only (RUO). Not for use in diagnostics.
SALSA MLPA Probemix P037 CLL-1 is a research use only (RUO) assay for the detection of deletions or duplications in various genes and chromosomal regions implicated in B-cell chronic lymphocytic leukemia (B-CLL) such as: 2p (MYCN, ALK, REL), 6q (TNFAIP3), 8p (TNFRSF10A/B), 8q (EIF3H, MYC), 9p21 (CDKN2A/B), 11q (ATM), chromosome 12, 13q14 (MIR15A, DLEU2/7) and 17p (TP53).
B-CLL is the most common hematologic neoplasm in Western countries and results in the progressive accumulation of morphologically mature but functionally incompetent CD5(+) CD23(+) B lymphocytes in bone marrow, blood, spleen and lymph nodes of the affected person. Chromosomal translocations are rare events in B-CLL. Copy number changes of certain chromosomal regions are however frequent and some are associated with disease prognosis.
More information is available at https://www.ncbi.nlm.nih.gov/books/NBK470433/
SALSA MLPA Probemix P038 CLL-2 contains more probes for the 11q region and different probes for chromosome 12, 13q14 and the TP53 gene. Moreover, it contains probes targeting the PTEN gene, 14q, chromosome 19, and probes specific for NOTCH1 p.P2514Rfs*4, SF3B1 p.K700E and MYD88 p.L265P point mutations. SALSA MLPA Probemix P040 CLL contains a selection of target genes and regions from P037 and P038 for the detection of copy number determination of 11q, chromosome 12, 13q14 and 17p13.
SALSA MLPA Probemix P037 CLL-1 is for research use only (RUO) in all territories.
A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).
These optional accessories can be ordered separately.
The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.
Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.
See this support article for commercially available positive samples that can be used with this product.