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digitalMLPA: Where MLPA Meets NGS for Broad Copy Number Certainty


Uniform coverage for accurate CNV results.



High gene coverage for comprehensive CNV detection.



Six easy steps with minimal hands on time and direct-to-sequencer loading capability.

Our SALSA® digitalMLPA™ products are for research use only (RUO). Not for use in diagnostic procedures.

digitalMLPA: unparalleled broad copy number certainty

SALSA® digitalMLPA™ is a powerful combination of our trusted SALSA® MLPA® technology and next-generation sequencing, meeting your large-scale copy number detection needs. With digitalMLPA, you can analyse a greater number of targets in a single reaction with only 20 ng of input DNA, while also reducing costs and turnaround times.

Video: What is digitalMLPA?

DNA helix.


Our current panel range focuses on hereditary cancer markers, as well as hematological malignancies, including multiple myeloma and acute lymphoblastic leukemia. In addition to our current products, we are actively developing new digitalMLPA assays for a wide range of applications.

Explore digitalMLPA panels


How does digitalMLPA work?

digitalMLPA is a PCR-based technique that enables the detection of up to 1000 targeted DNA sequences in a single multiplex reaction. After the PCR-based amplicon generation, each probe amplicon is quantified using an Illumina NGS platform. digitalMLPA does not require post-PCR clean up or library concentration measurements, making the technique efficient and user-friendly.

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Principle of digitalMLPA.

Coffalyser digitalMLPA

Coffalyser digitalMLPA™ is our free and easy-to-use data analysis software that makes analysing digitalMLPA experiments fast and effortless. Coffalyser digitalMLPA can automatically recognise digitalMLPA sequence reads from FASTQ files, and directly uses them for data analysis. Thanks to its advanced quality checks and algorithms, Coffalyser digitalMLPA can quickly detect and analyse aberrations in your samples, providing you with clear and detailed reports for every experiment.

Coffalyser digitalMLPA

Coffalyser digitalMLPA.

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