Choose your country to see the products for your location

SALSA MLPA Probemix P037 CLL-1

Chronic lymphocytic leukemia (CLL)

Region: Various

General information: The SALSA MLPA Probemix P037 CLL-1 is a research use only (RUO) assay for the detection of deletions or duplications in various genes and chromosomal regions implicated in B-cell chronic lymphocytic leukemia (B-CLL) such as: 2p (MYCN, ALK, REL), 6q (TNFAIP3), 8p (TNFRSF10A/B), 8q (EIF3H, MYC), 9p21 (CDKN2A/B), 11q (ATM), chromosome 12, 13q14 (MIR15A, DLEU2/7) and 17p (TP53).

B-CLL is the most common hematologic neoplasm in Western countries and results in the progressive accumulation of morphologically mature but functionally incompetent CD5(+) CD23(+) B lymphocytes in bone marrow, blood, spleen and lymph nodes of the affected person. Chromosomal translocations are rare events in B-CLL. Copy number changes of certain chromosomal regions are however frequent. Some of these have been found to be important prognostic markers of this disease.

The P038 CLL-2 probemix contains more probes for the 11q region and different probes for chromosome 12, 13q14 and the TP53 gene. Moreover, it contains probes targeting the PTEN gene, 14q, chromosome 19, and probes specific for NOTCH1 p.P2514*fs, SF3B1 p.K700E and MYD88 p.L265P point mutations. The P040 CLL probemix contains a selection of target genes and regions from P037 and P038 for the detection of del13q14, trisomy 12, del11q22-q23, and del17p13.

Probemix content: The SALSA MLPA Probemix P037-B1 CLL-1 contains 54 MLPA probes with amplification products between 130 and 500 nucleotides (nt). This includes 41 probes for 2p, 6q, 8p/q, 9p21, 11q, 12p/q, 13q and 17p chromosomal regions. In addition, 13 reference probes are included that target relatively copy number stable regions in CLL. Complete probe sequences and the identity of the genes detected by the reference probes are available online (www.mlpa.com).

This probemix contains nine quality control fragments generating amplification products between 64 and 105 nt: four DNA Quantity fragments (Q-fragments), two DNA Denaturation fragments (D-fragments), one Benchmark fragment, and one chromosome X and one chromosome Y-specific fragment. More information on how to interpret observations on these control fragments can be found in the MLPA General Protocol and online at www.mlpa.com.

Order Items

Probemix

Item no.
Description
Technology
Price
P037-025R
SALSA MLPA Probemix P037 CLL-1 – 25 rxn
€ 243.00
P037-050R
SALSA MLPA Probemix P037 CLL-1 – 50 rxn
€ 486.00
P037-100R
SALSA MLPA Probemix P037 CLL-1 – 100 rxn
€ 972.00

Required Reagents

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA EK1 reagent kit – 100 rxn – FAM
€ 300.00
EK1-Cy5
SALSA MLPA EK1 reagent kit – 100 rxn – Cy5
€ 300.00
EK5-FAM
SALSA MLPA EK5 reagent kit – 500 rxn – FAM
€ 1380.00
EK5-Cy5
SALSA MLPA EK5 reagent kit – 500 rxn – Cy5
€ 1380.00
EK20-FAM
SALSA MLPA EK20 reagent kit – 2000 rxn – FAM
€ 5295.00

Related Products

SALSA MLPA Probemix P038 CLL-2

Contains probes for 11q, 12p/q, 13q14, TP53 & PTEN genes and probes specific for NOTCH1 p.P2514*fs, SF3B1 p.K700E and MYD88 p.L265P point mutations.

SALSA MLPA Probemix P040 CLL

Contains probes for a selected target genes and regions from P037 and P038.

SALSA MLPA Probemix P041 ATM-1

Contain more probes for ATM on 11q.

SALSA MLPA Probemix P042 ATM-2

Contain more probes for ATM on 11q.

SALSA MLPA Probemix P047 RB1

Contain more probes for 13q14.3.

SALSA MLPA Probemix P056 TP53

Contains more probes for TP53.

SALSA MLPA Probemix P098 Wilson disease

Contain more probes for 13q14.3.

SALSA MLPA Probemix P252 NB mix 2

Contains more probes for 2p region.

SALSA MLPA Probemix P323 CDK4-HMGA2-MDM2

Includes more probes for chromosome 12.

Sign in

Don't have an account? Create one

Forgot password?

Select Your Country

Choose your country to see the products for your location