Choose your country to see the products for your location

SALSA MLPA Probemix P011 VWF mix 1

Von Willebrand disease (vWD)

Region: VWF 12p13.31

General information: The SALSA MLPA Probemix P011 / P012 VWF is a research use only (RUO) assay for the detection of deletions or duplications in the VWF gene, which is associated with von Willebrand Disease (vWD).

vWD is the most common hereditary coagulation abnormality described in humans. vWD is caused by a deficiency of von Willebrand factor (vWF), a blood glycoprotein which mediates the interaction of platelets with damaged endothelial surfaces at sites of vascular injury. vWF also acts as the carrier for factor VIIIC, thus increasing the half-life of VIIIC in the circulation. Furthermore, the vWF protein is involved in a number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic-uremic syndrome.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK7014/.

Probemix content:
The SALSA MLPA Probemix P011-B4 VWF mix 1 contains 37 MLPA probes with amplification products between 124 and 432 nucleotides (nt). This includes 28 probes targeting 26 out of 52 exons of the VWF gene (two probes for exons 2 and 6). In addition, nine reference probes are included that detect autosomal chromosomal locations.
The SALSA MLPA Probemix P012-B4 VWF mix 2 contains 37 MLPA probes with amplification products between 124 and 433 nucleotides (nt). This includes 28 probes targeting 28 out of 52 exons of the VWF gene. In addition, nine reference probes are included that detect autosomal chromosomal locations. Complete probe sequences and the identity of the genes detected by the reference probes are available online (www.mlpa.com).

These probemixes contain nine quality control fragments generating amplification products between 64 and 105 nt: four DNA Quantity fragments (Q-fragments), two DNA Denaturation fragments (D-fragments), one Benchmark fragment, one chromosome X, and one chromosome Y-specific fragment. More information on how to interpret observations on these control fragments can be found in the MLPA General Protocol and online at www.mlpa.com.

Order Items

Probemix

Item no.
Description
Technology
Price
P011-025R
SALSA MLPA Probemix P011 VWF mix 1 – 25 rxn
€ 243.00
P011-050R
SALSA MLPA Probemix P011 VWF mix 1 – 50 rxn
€ 486.00
P011-100R
SALSA MLPA Probemix P011 VWF mix 1 – 100 rxn
€ 972.00

Required Reagents (Sold Separately)

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA EK1 reagent kit – 100 rxn – FAM
€ 300.00
EK1-Cy5
SALSA MLPA EK1 reagent kit – 100 rxn – Cy5
€ 300.00
EK5-FAM
SALSA MLPA EK5 reagent kit – 500 rxn – FAM
€ 1380.00
EK5-Cy5
SALSA MLPA EK5 reagent kit – 500 rxn – Cy5
€ 1380.00
EK20-FAM
SALSA MLPA EK20 reagent kit – 2000 rxn – FAM
€ 5295.00

Related Products

SALSA MLPA Probemix P012 VWF mix 2

Contains probes for the vWF gene, involved in von Willibrand factor deficiency.

SALSA MLPA Probemix P178 F8

Contains probes for the F8 gene.

SALSA MLPA Probemix P207 F9

Contains probes for the F7 and F9 genes. In addition some probes for F8 are added.

SALSA MLPA Probemix P440 F10 + F11

Contains probes for F10 and F11 genes, involved in several bleeding disorders.

Sign in

Don't have an account? Create one

Forgot password?

Select Your Country

Choose your country to see the products for your location