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P440 F10 + F11

SALSA MLPA Probemix P440 F10 + F11 detects copy number variations in the F10 and F11 genes.

Specifications

Contents: 35 MLPA probes, including 9 probes for F10, and 16 probes for F11 (covering all exons of both genes).

Tissue: human genomic DNA.

Application: research on Rosenthal syndrome.

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P011 VWF mix 1

Contains probes for the VWF gene involved in von Willebrand disease.

P012 VWF mix 2

Contains probes for the VWF gene involved in von Willebrand disease.

P178 F8

Contains probes for the F8 gene, involved in Haemophilia A.

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General information

The SALSA MLPA Probemix P440 F10 + F11 is a research use only (RUO) assay for the detection of deletions or duplications in the F10 and F11 genes, which are associated with Rosenthal syndrome.

Factor X deficiency and Factor XI deficiency (Rosenthal syndrome) are two types of inherited autosomal recessive bleeding disorders characterised by haemorrhagic conditions of variable severity. Defects in the F10 gene on chromosome 13q34 are the main cause of Factor X deficiency. The vitamin K-dependent protein encoded by this gene is coagulation factor X. Defects in the F11 gene on chromosome 4q35.2 are the main cause of Factor XI deficiency. The protein encoded by this gene is coagulation factor XI.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK447152/.

Regulatory status

SALSA MLPA Probemix P440 F10 + F11 is for research use only (RUO) in all territories.

Product documentation

Version A2

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P440-025R
SALSA MLPA Probemix P440 F10 + F11 – 25 rxn
MLPA
€ 286.00
P440-050R
SALSA MLPA Probemix P440 F10 + F11 – 50 rxn
MLPA
€ 560.00
P440-100R
SALSA MLPA Probemix P440 F10 + F11 – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

The commercially available positive samples below can be used with the current (A2) version of this product.

F10

F11

Resources

General MLPA resources

MLPA education

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