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P012 VWF mix 2

SALSA MLPA probemixes P011 VWF mix 1 and P012 VWF mix 2 detect copy number variations in the VWF gene.

Specifications

Contents: P011 VWF mix 1 and P012 VWF mix 2 together contain 74 MLPA probes, including 56 probes for the VWF gene.

Tissue: human genomic DNA.

Application: research on von Willebrand Disease (vWD).

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P011 VWF mix 1

Contains probes for the vWF gene, involved in von Willibrand factor deficiency.

P178 F8

Contains probes for the F8 gene.

P207 F9

Contains probes for the F7 and F9 genes. In addition some probes for F8 are added.

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General information

The SALSA MLPA Probemix P011/P012 VWF is a research use only (RUO) assay for the detection of deletions or duplications in the VWF gene, which is associated with von Willebrand Disease (vWD).

vWD is the most common hereditary coagulation abnormality described in humans. vWD is caused by a deficiency of von Willebrand factor (vWF), a blood glycoprotein which mediates the interaction of platelets with damaged endothelial surfaces at sites of vascular injury. vWF also acts as the carrier for factor VIIIC, thus increasing the half-life of VIIIC in the circulation. Furthermore, the vWF protein is involved in a number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic-uremic syndrome.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK7014/.

Regulatory status

SALSA MLPA Probemix P012 VWF mix 2 is for research use only (RUO) in all territories.

Product documentation

Version B4

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P012-025R
SALSA MLPA Probemix P012 VWF mix 2 – 25 rxn
MLPA
€ 286.00
P012-050R
SALSA MLPA Probemix P012 VWF mix 2 – 50 rxn
MLPA
€ 560.00
P012-100R
SALSA MLPA Probemix P012 VWF mix 2 – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-Cy5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-Cy5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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