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SALSA MLPA Probemix P440 F10 + F11

Factor X deficiency; Factor XI deficiency

Region: F10 13q34; F11 4q35.2

General information: The SALSA MLPA Probemix P440 F10 + F11 is a research use only (RUO) assay for the detection of deletions or duplications in the F10 and F11 genes, which are associated with Rosenthal syndrome.

Factor X deficiency and Factor XI deficiency (Rosenthal syndrome) are two types of inherited autosomal recessive bleeding disorders characterised by haemorrhagic conditions of variable severity. Defects in the F10 gene on chromosome 13q34 are the main cause of Factor X deficiency. The vitamin K-dependent protein encoded by this gene is coagulation factor X. Defects in the F11 gene on chromosome 4q35.2 are the main cause of Factor XI deficiency. The protein encoded by this gene is coagulation factor XI.

Probemix content: The SALSA MLPA Probemix P440-A2 F10 + F11 contains 35 MLPA probes with amplification products between 166 and 454 nucleotides (nt). This includes nine probes for the F10 gene and 16 probes for the F11 gene, one probe for each exon and two probes for exon 1. In addition, ten reference probes are included that detect autosomal chromosomal locations. Complete probe sequences and the identity of the genes detected by the reference probes are available online (www.mlpa.com).

This probemix contains nine quality control fragments generating amplification products between 64 and 105 nt: four DNA Quantity fragments (Q-fragments), two DNA Denaturation fragments (D-fragments), one Benchmark fragment, one chromosome X, and one chromosome Y-specific fragment. More information on how to interpret observations on these control fragments can be found in the MLPA General Protocol and online at www.mlpa.com.

Order Items

Probemix

Item no.
Description
Technology
Price
P440-025R
SALSA MLPA Probemix P440 F10 + F11 – 25 rxn
€ 243.00
P440-050R
SALSA MLPA Probemix P440 F10 + F11 – 50 rxn
€ 486.00
P440-100R
SALSA MLPA Probemix P440 F10 + F11 – 100 rxn
€ 972.00

Required Reagents (Sold Separately)

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA EK1 reagent kit – 100 rxn – FAM
€ 300.00
EK1-Cy5
SALSA MLPA EK1 reagent kit – 100 rxn – Cy5
€ 300.00
EK5-FAM
SALSA MLPA EK5 reagent kit – 500 rxn – FAM
€ 1380.00
EK5-Cy5
SALSA MLPA EK5 reagent kit – 500 rxn – Cy5
€ 1380.00
EK20-FAM
SALSA MLPA EK20 reagent kit – 2000 rxn – FAM
€ 5295.00

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Contains probes for the F7, F8 and F9 genes, involved in Factor IX deficiency/Christmas disease.

SALSA MLPA Probemix P243 SERPING1 - F12

Contains probes for the SERPING1 and F12 genes.

SALSA MLPA Probemix P469 F5

Contains probes for the F5 gene.

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