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SALSA MLPA Probemix P207 F9

Factor VII deficiency; Hemophilia A; Hemophilia B

Region: F9 Xq27.1; F8 Xq28; F7 13q34

General information
The SALSA MLPA Probemix P207 F9 is a research use only (RUO) assay for the detection of deletions or duplications in the F7, F8 and F9 genes, encoding coagulation factors factor VII, factor VIII and factor IX, respectively. Coagulation factors play an important role in bleeding control and vessel repair. Deficiency in any of these genes may results in a bleeding disorders with different clinical manifestation: F7 is involved in factor VII deficiency, F8 in hemophilia A, and F9 in hemophilia B. Both hemophilia A and B are inherited in an X-linked manner, while factor VII deficiency is inherited in an autosomal recessive fashion.

More information is available at https://ghr.nlm.nih.gov/gene/F7, https://www.ncbi.nlm.nih.gov/books/NBK1404/ and https://www.ncbi.nlm.nih.gov/books/NBK1495/.

This SALSA MLPA probemix is not CE/FDA registered for use in diagnostic procedures. Purchase of this product includes a limited license for research purposes.

Probemix content

The SALSA MLPA Probemix P207-C4 F9 contains 38 MLPA probes with amplification products between 130 and 454 nucleotides (nt). This includes nine probes for the F7 gene, seven probes for the F8 gene and nine probes for the F9 gene. In addition, 13 reference probes are included that detect autosomal chromosomal locations. Complete probe sequences and the identity of the genes detected by the reference probes are available online (www.mrcholland.com).

This probemix contains nine quality control fragments generating amplification products between 64 and 105 nt: four DNA Quantity fragments (Q-fragments), two DNA Denaturation fragments (D-fragments), one Benchmark fragment, and one chromosome X and one chromosome Y-specific fragment. More information on how to interpret observations on these control fragments can be found in the MLPA General Protocol and online at www.mrcholland.com.

Order Items

Probemix

Item no.
Description
Technology
Price
P207-025R
SALSA MLPA Probemix P207 F9 – 25 rxn
€ 243.00
P207-050R
SALSA MLPA Probemix P207 F9 – 50 rxn
€ 486.00
P207-100R
SALSA MLPA Probemix P207 F9 – 100 rxn
€ 972.00

Required Reagents (Sold Separately)

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA EK1 reagent kit – 100 rxn – FAM
€ 300.00
EK1-Cy5
SALSA MLPA EK1 reagent kit – 100 rxn – Cy5
€ 300.00
EK5-FAM
SALSA MLPA EK5 reagent kit – 500 rxn – FAM
€ 1380.00
EK5-Cy5
SALSA MLPA EK5 reagent kit – 500 rxn – Cy5
€ 1380.00
EK20-FAM
SALSA MLPA EK20 reagent kit – 2000 rxn – FAM
€ 5295.00

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SALSA MLPA Probemix P012 VWF mix 2

Contains probes for the vWF gene, involved in von Willibrand factor deficiency.

SALSA MLPA Probemix P178 F8

Contains probes for the F8 gene, involved in Hemophilia A.

SALSA MLPA Probemix P440 F10 + F11

Contains probes for the F10 and the F11 gene, involved in bleeding disorders.

SALSA MLPA Probemix P469 F5

Contains probes for the F5 gene.

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