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SALSA MLPA Probemix P207 F9

Factor VII deficiency; Hemophilia A; Hemophilia B

Region: F9 Xq27.1; F8 Xq28; F7 13q34

General Information: The SALSA MLPA Probemix P207 F9 is a research use only (RUO) assay for the detection of deletions or duplications in the F7, F8 and F9 genes, providing instructions for making coagulation factors factor VII, factor VIII and factor IX, respectively.
Coagulation factors play an important role in bleeding control and vessel repair. Deficiency in any of these genes may results in a bleeding disorders with different clinical manifestation: F7 is involved in factor VII deficiency, F8 in hemophilia A, and F9 in hemophilia B. Both hemophilia A and B are inherited in an X-linked manner, while factor VII deficiency is inherited in an autosomal recessive fashion.

More information is available at https://ghr.nlm.nih.gov/gene/F7, and https://www.ncbi.nlm.nih.gov/books/NBK1404/, and https://www.ncbi.nlm.nih.gov/books/NBK1495/.

Probemix content: The SALSA MLPA Probemix P207-C4 F9 contains 38 MLPA probes with amplification products between 130 and 454 nt. This includes 25 probe(s) for the F7, F8 and F9 genes. In addition, 13 reference probes are included and detect different autosomal chromosomal locations. Complete probe sequences and the identity of the genes detected by the reference probes is available online (www.mlpa.com).

This probemix contains nine quality control fragments generating amplification products between 64 and 121 nt: four DNA Quantity Fragments (Q-fragments), two DNA Denaturation Fragments (D-fragments), one benchmark fragment, and one chromosome X and one chromosome Y-specific fragment. More information on how to interpret observations on these control fragments can be found in the MLPA General Protocol and online at www.mlpa.com.

Order Items

Probemix

Item no.
Description
Technology
Price
P207-025R
SALSA MLPA Probemix P207 F9 – 25 rxn
€ 243.00
P207-050R
SALSA MLPA Probemix P207 F9 – 50 rxn
€ 486.00
P207-100R
SALSA MLPA Probemix P207 F9 – 100 rxn
€ 972.00

Required Reagents

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA EK1 reagent kit – 100 rxn – FAM
€ 300.00
EK1-Cy5
SALSA MLPA EK1 reagent kit – 100 rxn – Cy5
€ 300.00
EK5-FAM
SALSA MLPA EK5 reagent kit – 500 rxn – FAM
€ 1380.00
EK5-Cy5
SALSA MLPA EK5 reagent kit – 500 rxn – Cy5
€ 1380.00
EK20-FAM
SALSA MLPA EK20 reagent kit – 2000 rxn – FAM
€ 5295.00

Related Products

SALSA MLPA Probemix P011 VWF mix 1

Contains probes for the vWF gene, involved in von Willibrand factor deficiency.

SALSA MLPA Probemix P012 VWF mix 2

Contains probes for the vWF gene, involved in von Willibrand factor deficiency.

SALSA MLPA Probemix P178 F8

Contains probes for the F8 gene, involved in Hemophilia A.

SALSA MLPA Probemix P440 F10 + F11

Contains probes for the F10 and the F11 gene, involved in bleeding disorders.

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