Choose your country to see the products for your location

SALSA MLPA Probemix P036 Subtelomeres Mix 1

Subtelomeric testing

Region: All subtelomeres

Intended use: This SALSA MLPA probemix P036 Subtelomeres Mix 1 is an in vitro diagnostic (IVD)1 or research use only (RUO) assay to detect deletion(s) and/or duplication(s) in subtelomeric regions in human DNA derived from peripheral blood, buccal swab, (un)cultured amniotic fluid obtained in week 16 of the pregnancy or later and free from blood contamination, (un)cultured chorionic villi free from maternal contamination, fetal blood, or products of conception as a potential cause of developmental delay, dysmorphic features, other congenital abnormalities and/or pregnancy loss. Detected abnormalities should always be confirmed by a designated MLPA follow-up probemix or other technique. The results of this test should be interpreted by a clinical molecular geneticist or equivalent.

1Please note that this probemix is for In Vitro Diagnostic use (IVD) in the countries specified at the end of this product description. In all other countries, the product is for Research Use Only (RUO).

Clinical background: Aberrant copy numbers of subtelomeric regions, e.g. due to an unbalanced translocation, are a frequent cause of developmental delay and congenital abnormalities. This P036-E3 Subtelomeres Mix 1 probemix for MLPA provides a faster, higher-throughput and more economical means than microarray analysis and FISH to identify individuals with a copy number change in one or more subtelomeric regions. MLPA cannot identify balanced rearrangements, however, and has a lower detection rate than microarray analysis. Detection rates depend strongly on the patient cohort tested. Examples are 5.9% (Ahn et al. 2007) when testing 455 patients or 3.9% (Stegmann et al. 2008) when testing a patient cohort in which normal G-banding analysis did not detect any abnormalities. Note that the results of Ahn et al. included some samples containing a genetic anomaly that had been inherited from an unaffected parent and which hence might have been a polymorphism without clinical significance. More information on and See the product description for several publications on probemix P036 Subtelomeres Mix 1.

Probemix content: This SALSA MLPA probemix P036 Subtelomeres Mix 1 contains 46 MLPA probes with amplification products between 130 and 483 nt: 2 probes for each chromosome. 41 probes are located in subtelomeric regions. No probes are present for the subtelomeric regions of the 5 acrocentric chromosomes (13, 14, 15, 21, 22). For these, an extra probe is included detecting the q arm, close to the centromere. The subtelomeric probes for the X and Y chromosome are identical as they detect sequences in the pseudoautosomal regions (PAR1 and PAR2) which are identical in chromosome X and Y. More information is present in the product description.

This Probemix contains ten quality control fragments generating amplification products between 64 and 121 nt: four DNA Quantity Fragments (Q-fragments), two DNA Denaturation Fragments (D-fragments), one benchmark fragment, and one chromosome X and two chromosome Y-specific fragments. More information on how to interpret observations on these control fragments can be found in the MLPA General Protocol and online at


Order Items


Item no.
SALSA MLPA Probemix P036 Subtelomeres Mix 1 – 25 rxn
€ 243.00
SALSA MLPA Probemix P036 Subtelomeres Mix 1 – 50 rxn
€ 486.00
SALSA MLPA Probemix P036 Subtelomeres Mix 1 – 100 rxn
€ 972.00

Required Reagents

Item no.
SALSA MLPA EK1 reagent kit – 100 rxn – FAM
€ 300.00
SALSA MLPA EK1 reagent kit – 100 rxn – Cy5
€ 300.00
SALSA MLPA EK5 reagent kit – 500 rxn – FAM
€ 1380.00
SALSA MLPA EK5 reagent kit – 500 rxn – Cy5
€ 1380.00
SALSA MLPA EK20 reagent kit – 2000 rxn – FAM
€ 5295.00

Related Products

SALSA MLPA Probemix P064 Microdeletion Syndromes-1B

Contains probes for several microdeletion syndromes.

SALSA MLPA Probemix P070 Subtelomeres Mix 2B

Contains a probe for every human subtelomere. Should be used together with the probemix P036.

SALSA MLPA Probemix P106 MRX

X-linked mental retardation.

SALSA MLPA Probemix P245 Microdeletion Syndromes-1A

Probes for 21 different microdeletion syndromes; can be used for primary screening of microdeletion syndromes.

Sign in

Don't have an account? Create one

Forgot password?

Select Your Country

Choose your country to see the products for your location


CE-marked products are for In Vitro Diagnostic (IVD) use only in EU (candidate) member states and members of the European Free Trade Association (EFTA).


IVD-registered in Israel.


IVD-registered in Morocco.