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NXtec D038 Carrier Plus

NXtec D038 Carrier Plus is a digitalMLPA assay that detects copy number variations and SNVs in 25 chromosomal regions.

Specifications

Contents: 718 probes, including 508 probes for 25 regions (of which 32 probes target the wild-type sequence of a particular SNV and 4 probes target the wild-type sequence at two locations simultaneously), and 10 probes detecting selected SNVs in SMN1, CYP21A2, HBB, DHCR7, HBA, ASPA, and MCOLN1.

Tissue: human genomic DNA.

Application: research on 25 chromosomal regions associated with autosomal recessive or X-linked conditions frequently tested for in carrier screening. For a full list of content, see the General information and the PIF for more details.

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

D028 Carrier Panel 1

Targets 9 regions associated with autosomal recessive or X-linked disorders that are frequently tested for in carrier analysis: DMD (1 probe per exon), SMN1, CYP21A2, HBA, HBB, CFTR, DFNB1, CLN3, and CTNS.

D008 DMD

Targets DMD, involved in Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), with 2 probes per DMD exon.

View all

Note that this assay must be used in combination with Coffalyser digitalMLPA v2.6.2 or newer.

General information

NXtec D038-A1 Carrier Plus is a research use only (RUO) assay for the detection of deletions, duplications, large gene conversions and the presence/absence of several selected SNVs in 25 chromosomal regions mentioned below, which are associated with autosomal recessive or X-linked conditions that are frequently tested for in carrier screening.

Coverage of D038 Carrier Plus (click to enlarge)

A frequent cause of genetic defects in the regions included in D038-A1 Carrier Plus are small (point) mutations, most of which will not be detected by using D038-A1 Carrier Plus. It is therefore strongly recommended to use this digitalMLPA probemix in combination with sequence analysis.

Sample number calculator

Use the calculator below to get an indication of the number of samples that can be included in a sequencing run. Click here if you are having issues loading or using the calculator, or if you would like more information about the calculation.

Regulatory status

NXtec D038 Carrier Plus is for research use only (RUO) in all territories.

SALSA Sample DNA for this product

The selection of suitable reference DNA samples with a normal copy number for all targets included in D038-A1 Carrier Plus can be complicated, as a significant portion of the global population is found to be a carrier of at least one variant. SALSA Sample DNA SD104 is a (pooled) female DNA sample with a normal copy number for all D038 Carrier Plus targets, as shown in the PIF under the column "Normal copy number". To facilitate correct data analysis and interpretation of copy numbers, it is strongly recommended to include at least three SD104 samples in each experiment. See section "Data analysis and reference samples" of the product description for further details.

SALSA Sample DNA SD104 is an integral part of NXtec D038 Carrier Plus, and cannot be ordered separately.

Product documentation

Version A1

Other versions

Contact us for earlier versions.

List prices

Note: SALSA Sample DNA SD104 is an integral part of NXtec D038 Carrier Plus, and cannot be ordered separately (more information).

Product

Item no.
Description
Technology
Price
D038-025R
NXtec D038 Carrier Plus – 25 rxn (including Sample DNA SD104)
digitalMLPA
€ 870.00
D038-050R
NXtec D038 Carrier Plus – 50 rxn (including Sample DNA SD104)
digitalMLPA
€ 1730.00
D038-100R
NXtec D038 Carrier Plus – 100 rxn (including Sample DNA SD104)
digitalMLPA
€ 3389.00

Required reagents

A general NXtec Reagent Kit is required for digitalMLPA NXtec experiments (to be ordered separately).

Item no.
Description
Technology
Price
DRK01-IL
NXtec Reagent Kit – 100 rxn (6 vials)
digitalMLPA
€ 361.00
DRK05-IL
NXtec Reagent Kit – 500 rxn (5×6 vials)
digitalMLPA
€ 1658.00
DRK20-IL
NXtec Reagent Kit – 2000 rxn (5×6 vials)
digitalMLPA
€ 6373.00
BP01-IL
NXtec Barcode Plate 1 (barcode solutions 1–96) – 768 rxn
digitalMLPA
€ 1789.00
BP02-IL
NXtec Barcode Plate 2 (barcode solutions 97–192) – 768 rxn
digitalMLPA
€ 1789.00
BP03-IL
NXtec Barcode Plate 3 (barcode solutions 193–288) – 768 rxn
digitalMLPA
€ 1789.00
BP04-IL
NXtec Barcode Plate 4 (barcode solutions 289–384) – 768 rxn
digitalMLPA
€ 1789.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

Positive samples for this product are not yet available online. Contact us if you need more information.

Resources

General digitalMLPA resources

digitalMLPA education

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First released on Nov 10, 2026