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NXtec D008 DMD

NXtec D008 DMD is a digitalMLPA assay that detects copy number variations in DMD, as well as X chromosome aneuploidies. This assay includes 2 probes per DMD exon for more robust copy number calling.

Specifications

Contents: 403 probes, including 158 probes for DMD, and 50 probes distributed across the X chromosome, upstream and downstream of DMD.

Tissue: human genomic DNA

Application: research on Duchenne muscular dystrophy (DMD), and Becker muscular dystrophy (BMD).

For research use only (RUO). Not for use in diagnostics.

Quick links

List Prices Documentation Compare DMD and BMD Products

Key related products

D028 Carrier Panel 1

Targets 9 regions associated with autosomal recessive or X-linked disorders that are frequently tested for in carrier analysis: DMD (1 probe per exon), SMN1, CYP21A2, HBA, HBB, CFTR, DFNB1, CLN3, and CTNS.

P034 DMD Mix 1

Targets DMD. Intended to be used together with P035 DMD Mix 2 to target all DMD exons with 1 probe per exon.

P035 DMD Mix 2

Targets DMD. Intended to be used together with P034 DMD Mix 1 to target all DMD exons with 1 probe per exon.

View all

Note that this assay must be used in combination with Coffalyser digitalMLPA v2.6.0 or newer.

Compare DMD and BMD products from MRC Holland.

General information

NXtec D008-A1 DMD is a research use only (RUO) assay for the detection of deletions or duplications in the dystrophin (DMD) gene, associated with Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). This assay includes additional coverage upstream and downstream of DMD to help determine the extent of DMD deletions or duplications, as well as detection of X chromosome aneuploidies.

Sample number calculator

Use the calculator below to get an indication of the number of samples that can be included in a sequencing run. Click here if you are having issues loading or using the calculator, or if you would like more information about the calculation.

Regulatory status

NXtec D008 DMD is for research use only (RUO) in all territories.

Product documentation

Version A1

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
D008-025R
NXtec D008 DMD – 25 rxn
digitalMLPA
€ 599.00
D008-050R
NXtec D008 DMD – 50 rxn
digitalMLPA
€ 1198.00
D008-100R
NXtec D008 DMD – 100 rxn
digitalMLPA
€ 2395.00

Required reagents

A general NXtec Reagent Kit is required for digitalMLPA NXtec experiments (to be ordered separately).

Item no.
Description
Technology
Price
DRK01-IL
NXtec Reagent Kit – 100 rxn (6 vials)
digitalMLPA
€ 361.00
DRK05-IL
NXtec Reagent Kit – 500 rxn (5×6 vials)
digitalMLPA
€ 1658.00
DRK20-IL
NXtec Reagent Kit – 2000 rxn (5×6 vials)
digitalMLPA
€ 6373.00
BP01-IL
NXtec Barcode Plate 1 (barcode solutions 1–96) – 768 rxn
digitalMLPA
€ 1789.00
BP03-IL
NXtec Barcode Plate 3 (barcode solutions 193–288) – 768 rxn
digitalMLPA
€ 1789.00
BP04-IL
NXtec Barcode Plate 4 (barcode solutions 289–384) – 768 rxn
digitalMLPA
€ 1789.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

See this support article for commercially available positive samples that can be used with this product.

Comparison of DMD and BMD products

MRC Holland offers four different assays for DMD and BMD.

Currently Viewing Currently Viewing Currently Viewing
D008 D028 P034 & P035
CE-marked no no yes
Technique digitalMLPA digitalMLPA MLPA
DMD coverage All 79 exons covered with 2 probes All 79 exons covered with 1 probe All 79 exons covered with 1 probe; additional probes for exon 1
Additional coverage 50 probes distributed across the X chromosome 131 probes targeting SMN1, CYP21A2, CFTR, CLN3, CTNS and the HBB, HBA and DFNB1 regions. -
# of reactions required for full DMD coverage 1 1 2
Equipment required Thermocycler with heated lid + compatible NGS instrument Thermocycler with heated lid + compatible NGS instrument Thermocycler with heated lid + compatible capillary electrophoresis instrument
Product page D008 D028 P034 & P035

Resources

D008 DMD

General digitalMLPA resources

digitalMLPA education

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First released on Jun 12, 2026