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P477 Head and neck carcinoma

SALSA MLPA Probemix P477 Head and neck carcinoma detects copy number variations in chromosomal regions and genes associated with head and neck squamous cell carcinoma.

Specifications

Contents: 49 MLPA probes, including 3 probes each for CUL3 and PIK3CA, 2 probes for SOX2, 3 probes each for FAT1, KIAA0825, EGFR, SNAI2, NFIB, and CCND1, 4 probes for FADD, and 3 probes each for TGIF1 and BCL2L1.

Tissue: human genomic DNA, including DNA from FFPE tissue.

Application: research on head and neck squamous cell carcinoma (HNSCC).

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

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General information

Probemix P477 Head and neck carcinoma is a research use only (RUO) assay for the detection of copy number alterations (CNAs) in multiple chromosomal regions and genes associated with distinct subgroups in head and neck squamous cell carcinoma (HNSCC): 2q36.2 (CUL3), 3q26.32-q26.33 (PIK3CA, SOX2), 4q35.2 (FAT1), 5q15 (KIAA0825), 7p11.2 (EGFR), 8q11.21 (SNAI2), 9p22.3 (NFIB), 11q13.2-q13.3 (CCND1, FADD), 18p11.31 (TGIF1), and 20q11.21 (BCL2L1).

Head and neck squamous cell carcinoma (HNSCC) – the most common form of head and neck cancer, accounting for ~8% of all cancers worldwide with higher frequencies in Southeast Asia and Asia-Pacific regions, and incidence rates are projected to increase. HNSCCs are characterized by clinical, phenotypic and genetic heterogeneity with unstable genomes, exhibiting multiple chromosomal gains and losses, and other structural aberrations. For the most prevalent HNSCCs, oral cavity squamous cell carcinomas (OCSCCs), distinct subgroups were identified (Muijlwijk T et al, 2024): (i) CNA-quiet with no or few CNAs, and (ii) CNA-other, featuring multiple CNAs in chromosomal regions reported in the Cancer Genome Atlas (TCGA) consortium publication (Cancer Genome Atlas Network, 2015). CNA-quiet OCSCCs have a distinct cancer driver gene profile, histological and clinical features, and have more favourable prognosis. P477 Head and neck carcinoma was shown to be a suitable pre-screening method to select CNA-other OCSCC (Muijlwijk T et al, 2024).

Regulatory status

SALSA MLPA Probemix P477 Head and neck carcinoma is for research use only (RUO) in all territories.

Product documentation

Version A2

Version A1

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P477-025R
SALSA MLPA Probemix P477 Head and neck carcinoma – 25 rxn
MLPA
€ 296.00
P477-050R
SALSA MLPA Probemix P477 Head and neck carcinoma – 50 rxn
MLPA
€ 580.00
P477-100R
SALSA MLPA Probemix P477 Head and neck carcinoma – 100 rxn
MLPA
€ 1135.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 361.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 361.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6373.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

See this support article for commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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