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P383 T-ALL

SALSA® MLPA® Probemix P383 T-ALL detects copy number variations in 13 chromosomal regions suggested to be of diagnostic and/or prognostic importance in T-lineage acute lymphoblastic leukemia (T-ALL).

Specifications

Contents: 56 MLPA probes, including 6 probes for the STIL-TAL1 region (1p33), 4 probes for LEF1 (4q25), 4 probes for CASP8AP2 (6q15), 3 probes for MYB (6q23), 3 probes for EZH2 (7q36) 6 probes for the MLLT3, MTAP and CDKN2A/B region (9p21), 4 probes for the NUP214-ABL1 fusion gene (9q34), 4 probes for PTEN (10q23), 2 probes for LMO1 (11p15), 6 probes for the RAG2-LMO2 region (11p13), 2 probes each for NF1 and SUZ12 (17q11), 4 probes for PTPN2 (18p11) and 4 probes for PHF6 (Xq26).

Tissue: human genomic DNA.

Application: research on T-lineage acute lymphoblastic leukemia (T-ALL).

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

ME024 9p21 CDKN2A/2B region

Contains probes for CDKN2A/2B (including several methylation-specific probes), MTAP, MIR31 and PAX5.

P056 TP53

Contains probes for each exon of the TP53 gene.

P081 NF1 mix 1

Contain probes for the NF1 gene.

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General information

The SALSA MLPA Probemix P383 T-ALL is a research use only (RUO) assay for the detection of deletions or duplications in 13 different chromosomal regions, which are suggested to be of diagnostic and/or prognostic importance in T-ALL.

T-lineage acute lymphoblastic leukemia (T-ALL) is a clonal malignant disorder of immature T-cells, which accounts for about 15% of paediatric and 25% of adult ALL cases (Iacobucci and Mullighan 2017). Although prognosis has improved due to effective treatment protocols, around 25% of paediatric and 50-70% of adult patients still experience relapse. T-ALL is genetically heterogeneous, and comprises multiple distinct subtypes defined by chromosomal rearrangements that usually involve one of the T-cell receptor (TCR) loci, but non-TCR-driven translocations are also detected. In addition, genome-wide characterisation has identified several novel amplifications, deletions and point mutations in T-ALL samples that are of interest to better define T-ALL subgroups (Girardi et al. 2017).

Regulatory status

SALSA MLPA Probemix P383 T-ALL is for research use only (RUO) in all territories.

Product documentation

Version A2

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P383-025R
SALSA MLPA Probemix P383 T-ALL – 25 rxn
MLPA
€ 286.00
P383-050R
SALSA MLPA Probemix P383 T-ALL – 50 rxn
MLPA
€ 560.00
P383-100R
SALSA MLPA Probemix P383 T-ALL – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-Cy5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-Cy5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

See this support article for commercially available positive samples that have been tested with this product.

Resources

General MLPA resources

MLPA education

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