Choose your country to see the products for your location

P329 CRLF2-CSF2RA-IL3RA

SALSA MLPA Probemix P329 CRLF2-CSF2RA-IL3RA detects copy number variations in the CRLF2, CSF2RA and IL3RA genes.

Specifications

Contents: 47 MLPA probes, including 5 probes for CRLF2, 13 probes for CSF2RA, and 7 probes for IL3RA.

Tissue: human genomic DNA.

Application: research on B-cell acute lymphoblastic leukaemia (ALL).

For research use only (RUO). Not for use in diagnostics.

Quick links

List Prices Documentation

Key related products

ME024 9p21 CDKN2A/2B region

Contains probes for the 9p21 region, including CDKN2A and CDKN2B genes, for detection of both copy number and methylation status.

P018 SHOX

Contains probes for SHOX gene and several other genes in the PAR1 region.

P202 IKZF1-ERG

Contains probes for IKZF1, ERG and CDKN2A/B and for the 14q32.33 region.

View all

General information

SALSA MLPA Probemix P329 CRLF2-CSF2RA-IL3RA is a research use only (RUO) assay for the detection of deletions or duplications in the CRLF2, CSF2RA and IL3RA genes, which are associated with B-cell acute lymphoblastic leukaemia (ALL).

The first 3 Mb of the X and Y chromosomes are homologous and are called the pseudoautosomal region 1 (PAR1). Among the genes in this PAR1 region are CRLF2, CSF2RA and IL3RA. The chromosomal region containing these genes has been linked to lymphoid cell transformation in B-ALL. Frequent rearrangements in the PAR1 region are reported in ALL (Russell et al. 2009 and Mullighan et al. 2009), including a deletion of the IL3RA and CSF2RA genes resulting in the overexpression of the CRLF2 gene in 7% of individuals with B-progenitor ALL and 53% of individuals with ALL associated with Down syndrome. Deletions in the PAR1 region in ALL are an indication for poor prognosis (Mullighan et al. 2009), especially when combined with other gene deletions such as IKZF1, CDKN2A, CDKN2B and PAX5 (Stanulla et al. 2018, Kiss et al. 2020).

Regulatory status

SALSA MLPA Probemix P329 CRLF2-CSF2RA-IL3RA is for research use only (RUO) in all territories.

Product documentation

Version B1

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P329-025R
SALSA MLPA Probemix P329 CRLF2-CSF2RA-IL3RA – 25 rxn
MLPA
€ 296.00
P329-050R
SALSA MLPA Probemix P329 CRLF2-CSF2RA-IL3RA – 50 rxn
MLPA
€ 580.00
P329-100R
SALSA MLPA Probemix P329 CRLF2-CSF2RA-IL3RA – 100 rxn
MLPA
€ 1135.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 361.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 361.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6373.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

See this support article for commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

This site uses cookies to help improve your online experience. Learn more
No, thank you accept

Sign in

Don't have an account? Create one

Forgot password?

Select Your Country

Choose your country to see the products for your location