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SALSA MLPA Probemix P239 BRCA1 region

Breast and ovarian cancer, hereditary (HBOC)

Region: BRCA1 region

General Information: The SALSA MLPA Probemix P239 BRCA1 region is a research use only (RUO) assay for the detection of deletions or duplications in the BRCA1 region, which is associated with hereditary breast cancer.

Defects in the BRCA1 gene on human chromosome 17q21 are an important cause of hereditary breast cancer. This SALSA® MLPA® P239 BRCA1 region probemix can be used to characterize deletions/duplications that extend to the region up- and downstream of the BRCA1 gene. For primary screening of BRCA1, we recommend using SALSA® MLPA® probemix P002. SALSA® MLPA® probemix P239 BRCA1 region is developed for research purposes to investigate the extent of BRCA1 deletions/duplications.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1247/.

Probemix content: The SALSA MLPA Probemix P239-C1 BRCA1 region contains 32 MLPA probes with amplification products between 130 and 400 nt. This includes 11 probes for the upstream region of BRCA1 gene including the NBR1, NBR2 genes and the BRCA1 pseudogene. Furthermore, five probes for the BRCA1 gene are included and six probes for the downstream region of the BRCA1 gene including the VAT1 and RND2 genes. In addition, ten reference probes are included and detect ten different autosomal chromosomal locations / target relatively quiet regions in the particular type of tumour studied. Complete probe sequences and the identity of the genes detected by the reference probes is available online (www.mlpa.com).

This Probemix contains nine quality control fragments generating amplification products between 64 and 105 nt: four DNA Quantity Fragments (Q-fragments), two DNA Denaturation Fragments (D-fragments), one benchmark fragment, one chromosome X, and one chromosome Y-specific fragment. More information on how to interpret observations on these control fragments can be found in the MLPA General Protocol and online at www.mlpa.com.


Order Items

Probemix

Item no.
Description
Technology
Price
P239-025R
SALSA MLPA Probemix P239 BRCA1 region – 25 rxn
€ 243.00
P239-050R
SALSA MLPA Probemix P239 BRCA1 region – 50 rxn
€ 486.00
P239-100R
SALSA MLPA Probemix P239 BRCA1 region – 100 rxn
€ 972.00

Required Reagents (Sold Separately)

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA EK1 reagent kit – 100 rxn – FAM
€ 300.00
EK1-Cy5
SALSA MLPA EK1 reagent kit – 100 rxn – Cy5
€ 300.00
EK5-FAM
SALSA MLPA EK5 reagent kit – 500 rxn – FAM
€ 1380.00
EK5-Cy5
SALSA MLPA EK5 reagent kit – 500 rxn – Cy5
€ 1380.00
EK20-FAM
SALSA MLPA EK20 reagent kit – 2000 rxn – FAM
€ 5295.00

Related Products

SALSA MLPA Probemix P002 BRCA1

Contains probes for the BRCA1 gene, involved in breast and ovarian cancer. It should be used for primary screening of BRCA1.

SALSA MLPA Probemix P041 ATM-1

Contains probes for the ATM gene, involved in breast cancer and Ataxia Telangiectasia.

SALSA MLPA Probemix P042 ATM-2

Contains probes for the ATM gene, involved in breast cancer and Ataxia Telangiectasia.

SALSA MLPA Probemix P045 BRCA2/CHEK2

Contains probes for the BRCA2 and CHEK2 genes, involved in breast and ovarian cancer.

SALSA MLPA Probemix P056 TP53

Contains probes for the TP53 gene, involved in Li-Fraumeni syndrome.

SALSA MLPA Probemix P057 FANCD2-PALB2

Contains probes for the FANCD2 and PALB2 genes, involved in Fanconi Anemia.

SALSA MLPA Probemix P077 BRCA2 Confirmation

Contains probes for the BRCA2 gene. It can be used to confirm the results obtained with P045 or P090.

SALSA MLPA Probemix P087 BRCA1 Confirmation

Contains probes for the BRCA1 gene. It can be used to confirm the results obtained with P002.

SALSA MLPA Probemix P090 BRCA2

Contains the same probes for the BRCA2 gene as P045.

SALSA MLPA Probemix P190 CHEK2

Contains probes for the CHEK2, ATM and TP53 genes, involved in cancer.

SALSA MLPA Probemix P225 PTEN

Contains probes for the PTEN gene, involved in breast cancer.

SALSA MLPA Probemix P240 BRIP1/CHEK1

Contains probes for the BRIP1 and CHEK1 genes, involved in breast cancer.

SALSA MLPA Probemix P260 PALB2-RAD50-RAD51C-RAD51D

Contains probes for the PALB2, RAD50, RAD51C and RAD51D genes, involved in breast and ovarian cancer.

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