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SALSA MLPA Probemix P239 BRCA1 region

Breast cancer

Region: BRCA1 region

General Information: The SALSA MLPA Probemix P239 BRCA1 region is a research use only (RUO) assay for the detection of deletions or duplications in the BRCA1 region, which is associated with hereditary breast cancer.

Defects in the BRCA1 gene on human chromosome 17q21 are an important cause of hereditary breast cancer. This SALSA® MLPA® P239 BRCA1 region probemix can be used to characterize deletions/duplications that extend to the region up- and downstream of the BRCA1 gene. For primary screening of BRCA1, we recommend using SALSA® MLPA® probemix P002. SALSA® MLPA® probemix P239 BRCA1 region is developed for research purposes to investigate the extent of BRCA1 deletions/duplications.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1247/.

Probemix content: The SALSA MLPA Probemix P239-C1 BRCA1 region contains 32 MLPA probes with amplification products between 130 and 400 nt. This includes 11 probes for the upstream region of BRCA1 gene including the NBR1, NBR2 genes and the BRCA1 pseudogene. Furthermore, five probes for the BRCA1 gene are included and six probes for the downstream region of the BRCA1 gene including the VAT1 and RND2 genes. In addition, ten reference probes are included and detect ten different autosomal chromosomal locations / target relatively quiet regions in the particular type of tumour studied. Complete probe sequences and the identity of the genes detected by the reference probes is available online (www.mlpa.com).

This Probemix contains nine quality control fragments generating amplification products between 64 and 105 nt: four DNA Quantity Fragments (Q-fragments), two DNA Denaturation Fragments (D-fragments), one benchmark fragment, one chromosome X, and one chromosome Y-specific fragment. More information on how to interpret observations on these control fragments can be found in the MLPA General Protocol and online at www.mlpa.com.


Order Items

Probemix

Item no.
Description
Technology
Price
P239-025R
SALSA MLPA Probemix P239 BRCA1 region – 25 rxn
€ 243.00
P239-050R
SALSA MLPA Probemix P239 BRCA1 region – 50 rxn
€ 486.00
P239-100R
SALSA MLPA Probemix P239 BRCA1 region – 100 rxn
€ 972.00

Required Reagents

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA EK1 reagent kit – 100 rxn – FAM
€ 300.00
EK1-Cy5
SALSA MLPA EK1 reagent kit – 100 rxn – Cy5
€ 300.00
EK5-FAM
SALSA MLPA EK5 reagent kit – 500 rxn – FAM
€ 1380.00
EK5-Cy5
SALSA MLPA EK5 reagent kit – 500 rxn – Cy5
€ 1380.00
EK20-FAM
SALSA MLPA EK20 reagent kit – 2000 rxn – FAM
€ 5295.00

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SALSA MLPA Probemix P090 BRCA2

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Mutations in BRIP1 have been linked to a higher risk on breast cancer.

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