Choose your country to see the products for your location

P240 BRIP1/CHEK1

SALSA MLPA Probemix P240 BRIP1/CHEK1 detects copy number variations in the BRIP1 and CHEK1 genes.

Specifications

Contents: 44 MLPA probes, including 20 probes for BRIP1, and 13 probes for CHEK1.

Tissue: human genomic DNA.

Application: research on hereditary predisposition to cancer.

For research use only (RUO). Not for use in diagnostics.

Quick links

List Prices Documentation

Key related products

P002 BRCA1

Hereditary breast cancer; primary screening BRCA1.

P041 ATM-1

Mutations in ATM have been linked to a higher risk of breast cancer.

P042 ATM-2

Mutations in ATM have been linked to a higher risk of breast cancer.

View all

General information

The SALSA MLPA Probemix P240 BRIP1/CHEK1 is a research use only (RUO) assay for the detection of deletions or duplications in the BRIP1 and CHEK1 genes, which are associated with hereditary predisposition to cancer.

The BRIP1 gene may be a target of germline cancer-inducing mutations and has been shown to be mutated in FA-J (FANCJ) cells (Levran et al. 2005). The protein encoded by the BRIP1 gene is a member of the RecQ DEAH helicase family that interacts with the BRCT repeats of breast cancer type 1 susceptibility protein (BRCA1). The bound complex is important in normal double-strand break repair function of BRCA1.

CHEK1 plays an essential role in the mammalian DNA damage checkpoint (G2/M DNA damage checkpoint), embryonic development, tumour suppression and is regulated by the ATR gene (Liu et al. 2000).

Regulatory status

SALSA MLPA Probemix P240 BRIP1/CHEK1 is for research use only (RUO) in all territories.

Product documentation

Version A5

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P240-025R
SALSA MLPA Probemix P240 BRIP1/CHEK1 – 25 rxn
MLPA
€ 286.00
P240-050R
SALSA MLPA Probemix P240 BRIP1/CHEK1 – 50 rxn
MLPA
€ 560.00
P240-100R
SALSA MLPA Probemix P240 BRIP1/CHEK1 – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

This site uses cookies to help improve your online experience. Learn more
No, thank you accept

Sign in

Don't have an account? Create one

Forgot password?

Select Your Country

Choose your country to see the products for your location