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SALSA MLPA Probemix P078 Breast tumour

Breast tumour

Region: various

General information: The SALSA MLPA Probemix P078 Breast tumour is a research use only (RUO) assay for the detection of deletions or duplications in 6q25 (ESR1), 7p11 (EGFR), 8p12-p11 (ZNF703, FGFR1, ADAM9, IKBKB), 8q13-q24 (PRDM14, MTDH, MYC), 11q13 (CCND1, EMSY), 16q22 (CDH1), 17q11-q25 (ERBB2, TOP2A, MAPT, PPM1D, BIRC5), 19q12 (CCNE1) and 20q13 (AURKA), which are suggested to be of diagnostic/clinical importance in breast cancer. See Table 1 and Table 2a for detailed information about all included chromosomal regions and genes.

Probemix content: The SALSA MLPA Probemix P078-D2 Breast tumour contains 55 MLPA probes with amplification products between 127 and 500 nt. This includes in total 41 probes for the following chromosomal regions: 6q25 (ESR1), 7p11 (EGFR), 8p12-p11 (ZNF703, FGFR1, ADAM9, IKBKB), 8q13-q24 (PRDM14, MTDH, MYC), 11q13 (CCND1, EMSY), 16q22 (CDH1), 17q11-q25 (ERBB2, TOP2A, MAPT, PPM1D, BIRC5), 19q12 (CCNE1) and 20q13 (AURKA). In addition, 14 reference probes are included which target relatively copy number stable regions in various tumour types including breast cancer. The identity of the genes detected by the reference probes is available in Table 2b. Complete probe sequences are available online (www.mlpa.com).

This probemix contains nine quality control fragments generating amplification products between 64 and 121 nucleotides (nt): four DNA Quantity fragments (Q-fragments), two DNA Denaturation fragments (D-fragments), one Benchmark fragment, and one chromosome X- and one chromosome Y-specific fragment. More information on how to interpret observations on these control fragments can be found in the MLPA General Protocol and online at www.mlpa.com.

Order Items

Probemix

Item no.
Description
Technology
Price
P078-025R
SALSA MLPA Probemix P078 Breast tumour – 25 rxn
€ 243.00
P078-050R
SALSA MLPA Probemix P078 Breast tumour – 50 rxn
€ 486.00
P078-100R
SALSA MLPA Probemix P078 Breast tumour – 100 rxn
€ 972.00

Required Reagents (Sold Separately)

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA EK1 reagent kit – 100 rxn – FAM
€ 300.00
EK1-Cy5
SALSA MLPA EK1 reagent kit – 100 rxn – Cy5
€ 300.00
EK5-FAM
SALSA MLPA EK5 reagent kit – 500 rxn – FAM
€ 1380.00
EK5-Cy5
SALSA MLPA EK5 reagent kit – 500 rxn – Cy5
€ 1380.00
EK20-FAM
SALSA MLPA EK20 reagent kit – 2000 rxn – FAM
€ 5295.00

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