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SALSA MLPA Probemix P032 FANCA mix 2

Fanconi anemia (FA)

Region: FANCA 16q24.3

General Information: These SALSA MLPA Probemixes P031/P032 FANCA are research use only (RUO) assays for the detection of deletions or duplications in the FANCA gene, which is associated with Fanconi Anemia.

Fanconi Anemia (FA) is an autosomal recessive disorder characterised by physical abnormalities, bone marrow failure, and increased risk of malignancy. Mutations in several different genes can result in FA, however defects of the FANCA gene are the most frequent cause (60-70% of cases). Known defects of the FANCA gene include point mutations, small deletions/insertions and deletions of one or more complete exons.

Probemix content: The SALSA MLPA Probemix P031-B3 FANCA mix 1 contains 31 MLPA probes with amplification products between 137 and 409 nt. This includes 22 probes for the FANCA gene. In addition, nine reference probes are included and detect nine different autosomal chromosomal locations. Complete probe sequences and the identity of the genes detected by the reference probes is available online (www.mlpa.com).

The SALSA MLPA Probemix P032-B3 FANCA mix 2 contains 32 MLPA probes with amplification products between 140 and 418 nt. This includes 21 probes for the FANCA gene and one flanking probe in the GAS8 gene. In addition, ten reference probes are included and detect ten different autosomal chromosomal locations. Complete probe sequences and the identity of the genes detected by the reference probes is available online (www.mlpa.com).

These Probemixes contains nine quality control fragments generating amplification products between 64 and 121 nt: four DNA Quantity Fragments (Q-fragments), two DNA Denaturation Fragments (D-fragments), one benchmark fragment, and one chromosome X and one chromosome Y-specific fragment. More information on how to interpret observations on these control fragments can be found in the MLPA General Protocol and online at (www.mlpa.com).

Order Items

Probemix

Item no.
Description
Technology
Price
P032-025R
SALSA MLPA Probemix P032 FANCA mix 2 – 25 rxn
€ 243.00
P032-050R
SALSA MLPA Probemix P032 FANCA mix 2 – 50 rxn
€ 486.00
P032-100R
SALSA MLPA Probemix P032 FANCA mix 2 – 100 rxn
€ 972.00

Required Reagents

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA EK1 reagent kit – 100 rxn – FAM
€ 300.00
EK1-Cy5
SALSA MLPA EK1 reagent kit – 100 rxn – Cy5
€ 300.00
EK5-FAM
SALSA MLPA EK5 reagent kit – 500 rxn – FAM
€ 1380.00
EK5-Cy5
SALSA MLPA EK5 reagent kit – 500 rxn – Cy5
€ 1380.00
EK20-FAM
SALSA MLPA EK20 reagent kit – 2000 rxn – FAM
€ 5295.00

Related Products

SALSA MLPA Probemix P031 FANCA mix 1

Fanconi Anemia group A – genes included: FANCA.

SALSA MLPA Probemix P057 FANCD2-PALB2

Fanconi Anemia. Genes included: FANCD2, PALB2.

SALSA MLPA Probemix P113 FANCB

Fanconi Anemia group B. Gene included: FANCB.

SALSA MLPA Probemix P260 PALB2-RAD50-RAD51C-RAD51D

Fanconi Anemia. Genes included: PALB2, RAD50, RAD51C and RAD51D.

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