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P113 FANCB

SALSA MLPA Probemix P113 FANCB detects copy number variations in the FANCB gene.

Specifications

Contents: 25 MLPA probes, including 16 probes for the FANCB region (covering all FANBC exons).

Tissue: human genomic DNA.

Application: research on Fanconi anemia (FA).

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P031 FANCA mix 1

Fanconi Anemia group A – genes included: FANCA.

P032 FANCA mix 2

Fanconi Anemia group A – genes included: FANCA.

P057 FANCD2-PALB2

Fanconi Anemia – genes included: FANCD2, PALB2.

View all

General information

The SALSA MLPA Probemix P113 FANCB is a research use only (RUO) assay for the detection of deletions or duplications in the FANCB gene, which is associated with Fanconi anemia.

Fanconi anemia is a rare genetically heterogeneous recessive disorder characterized by congenital malformations, progressive bone marrow failure, and predisposition to cancer due to cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. FANCB is the only gene known to cause X-linked Fanconi Anemia. Patients harboring the X-linked FANCB pathogenic variants usually present with severe congenital malformations resembling VACTERL syndrome with hydrocephalus.

The FANCB gene (10 exons), spans ~29.7 kb of genomic DNA and is located on chromosome Xp22.2, ~14.8 Mb from the p telomere.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1401/.

Regulatory status

SALSA MLPA Probemix P113 FANCB is for research use only (RUO) in all territories.

Product documentation

Version B1

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P113-025R
SALSA MLPA Probemix P113 FANCB – 25 rxn
MLPA
€ 286.00
P113-050R
SALSA MLPA Probemix P113 FANCB – 50 rxn
MLPA
€ 560.00
P113-100R
SALSA MLPA Probemix P113 FANCB – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-Cy5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-Cy5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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