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SALSA MLPA Probemixes P031 FANCA Mix 1 and P032 FANCA Mix 2 detect copy number variation in the FANCA gene.
Contents: P031 FANCA mix 1 and P032 FANCA mix 2 together contain 63 MLPA probes, including 43 probes for the FANCA gene (covering all exons).
Tissue: human genomic DNA.
Application: research on Fanconi anemia (FA).
For research use only (RUO). Not for use in diagnostics.
Fanconi Anemia (FA) is an autosomal recessive disorder characterised by physical abnormalities, bone marrow failure, and increased risk of malignancy. Mutations in several different genes can result in FA, however defects of the FANCA gene are the most frequent cause (60-70% of cases). Known defects of the FANCA gene include point mutations, small deletions/insertions and deletions of one or more complete exons.
The FANCA gene (43 exons) spans ~79 kb of genomic DNA and is located on chromosome 16q24.3, ~88 Mb from the p-telomere (close to the q-telomere).
More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1401/.
SALSA MLPA Probemix P031 FANCA mix 1 is for research use only (RUO) in all territories.
A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).
The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.
Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.
See this support article for commercially available positive samples that can be used with this product.