News Archive
Introducing NXtec: An Update to digitalMLPA Product Naming
Introducing NXtec—the new product line name for all currently available digitalMLPA assays. This change helps us clearly distinguish our current assays from future variants that may require different protocols or reagents.
Our Products are IVDR-Certified!
We have successfully obtained our certification under the new In Vitro Diagnostic Regulation (IVDR; 2017/746)! The first batch of flagship products are already available on the market under the new IVDR, well in advance of the transition period deadline.
Celebrating 40 Years of MRC Holland
This year marks the 40th anniversary of MRC Holland!
GENESUM - a Public-Private Collaboration Between MRC Holland and the LUMC
We are thrilled to announce a new public-private partnership between MRC Holland and the Leiden University Medical Center (LUMC).
Improved – P101 STK11 - Featuring New and Improved Denaturation Control Probes
P101 STK11, now available on the market under the IVDR, just received a major update, with the recently released C1 version displaying exceptional sensitivity in the detection of any denaturation issues. It features two improved and two newly added denaturation control probes, one target probe replacement, and a complete overhaul of the product's reference probes.
Documentation Update - Sequences Displayed in Probe Sequence Sheets (MLPA Probemixes)
We recently updated our probe sequence sheet template to display partial probe sequences in place of the full sequences. In the updated documentation, 20 nucleotides on either side of the probe's ligation site are displayed.
Improved – P148 TGFBR1-TGFBR2-TGFB2-SMAD3 – Featuring New Probes Targeting TGFB2 and SMAD3
The new C1 version of P148 TGFBR1-TGFBR2-TGFB2-SMAD3 is now available on the market, featuring several new probes targeting TGFB2 and SMAD3, and a number of improved target and reference probes that together increase the coverage and robustness of the probemix.
MLPA and digitalMLPA in Pediatric Acute Lymphoblastic Leukemia
A study published in Modern Pathology by researchers from Semmelweis University (Budapest, Hungary), in collaboration with scientists from MRC Holland, utilised MLPA and digitalMLPA in combination with DNA and RNA sequencing to extensively characterise a nationwide cohort of 192 pediatric acute lymphoblastic leukemia (ALL) patients.
Wanted: DNA Samples
MRC Holland is looking for DNA samples for the development and quality control of our many products.
Coffalyser.Net - License Renewal or Update - User Action May Be Required
Action may be required from users of Coffalyser.Net, our free analysis software. Users of the latest version of Coffalyser.Net (v.250317.1029) do not need to perform any action. Users of v.240129.1959 are required to renew their license which is easy to do and free of charge. Users of older versions of Coffalyser.Net are required to update to version v.240129.1959 or v.250317.1029. This is required for users making use of both preconfigured, as well as custom SQL Servers.