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P425 Multiple Myeloma

SALSA MLPA Probemix P425 Multiple Myeloma detects copy number variations in various genes and regions associated with multiple myeloma (MM).

Specifications

Contents: 57 MLPA probes, including 46 probes for 1p32-p12, 1q21-q23, 5q31, chromosome 9, 12p13, 13q14-q22 (RB1-DLEU2-DIS3), 14q32 (TRAF3), chromosome 15, 16q12-q23 (CYLD-WWOX) and 17p13 (TP53).

Tissue: human genomic DNA.

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P037 CLL-1

Contains 8 probes for the 13q region (RB1-DLEU1/2/7).

P038 CLL-2

Contains 7 probes for the 13q region (RB1-DLEU1/2/7).

P056 TP53

Contains probes for each exon of TP53 gene.

View all

General information

The SALSA MLPA Probemix P425 Multiple Myeloma is a research use only (RUO) assay for the detection of deletions or duplications in the following chromosomal regions and target genes: 1p32-p12, 1q21-q23, 5q31, chr. 9, 12p13, 13q14-q22 (RB1-DLEU2-DIS3), 14q32 (TRAF3), chr. 15, 16q12 (CYLD), 16q23 (WWOX) and 17p13 (TP53). These regions and genes are suggested to be of prognostic relevance in MM.

Multiple myeloma (MM) is a clonal B-cell disorder characterized by malignant proliferation of monoclonal plasma cells. MM cases present a common histological and morphological diagnosis, but enormous genetic and molecular complexity as well as marked variations in clinical characteristics and in patient survival. Recent progress in molecular cytogenetics has improved our understanding of the pathogenesis of MM and has also provided reasoning for molecular sub-classification of MM. Primary cytogenetic abnormalities detected in the initial stages of MM include trisomies (commonly involving chromosomes 5, 7, 9, 11, 13 and 15) and immunoglobulin heavy chain (IgH) translocations. Upon disease progression, secondary genetic alterations take place, frequently including del17p or monosomy 17, del13q or monosomy 13, del1p and 1p gain. MLPA has been shown to be a reliable technique to detect copy number alterations in MM (Alpar et al. 2013 and Boyle et al. 2014). As balanced translocations also have a high importance in the prognostic classification of MM patients, MLPA and i-FISH are suggested to be applied as complimentary techniques in this entity.

Regulatory status

SALSA MLPA Probemix P425 Multiple Myeloma is for research use only (RUO) in all territories.

Product documentation

Version B2

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P425-025R
SALSA MLPA Probemix P425 Multiple Myeloma – 25 rxn
MLPA
€ 286.00
P425-050R
SALSA MLPA Probemix P425 Multiple Myeloma – 50 rxn
MLPA
€ 560.00
P425-100R
SALSA MLPA Probemix P425 Multiple Myeloma – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-Cy5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-Cy5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

See this support article for commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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