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P417 BAP1

SALSA MLPA Probemix P417 BAP1 detects copy number variations in the BAP1 gene.

Specifications

Contents: 42 MLPA probes, including 17 probes for BAP1.

Tissue: human genomic DNA, including DNA from FFPE tissue.

Application: research on BAP1 tumour predisposition syndrome.

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

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Contains probes for all exons of the SDHB, SDHC, SDHD, SDHAF1 and SDHAF2 genes.

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General information

The SALSA MLPA Probemix P417 BAP1 is a research use only (RUO) assay for the detection of deletions or duplications in the BAP1 gene, which is associated with BAP1 tumour predisposition syndrome.

BAP1 tumour predisposition syndrome (OMIM# 614327) is inherited in an autosomal dominant manner. Individuals carrying heterozygous BAP1 mutations are at high-risk for the development of a variety of tumours, including benign melanocytic tumours as well as several malignant tumours, including uveal melanoma, cutaneous melanoma, malignant mesothelioma upon exposure to asbestos, and other cancer types, such as renal cell carcinoma, basal cell carcinoma, lung adenocarcinoma and meningioma (Wiesner et al. 2011, Abdel-Rahman et al. 2011, Boru et al. 2019).

In addition, research suggests that uveal melanoma with monosomy of chromosome 3 (frequency 50-60% of all uveal melanomas) represents a distinct pathological entity as compared to uveal melanoma with normal disomy 3. The putative target gene on the 3p arm is BAP1 on 3p21.1, as inactivating somatic mutations of BAP1 are identified in >80% of patients with metastasizing uveal melanoma (Harbour et al. 2010). Moreover, BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma (Testa et al. 2011, Bott et al. 2011).

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK390611/

Regulatory status

SALSA MLPA Probemix P417 BAP1 is for research use only (RUO) in all territories.

Product documentation

Version B3

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P417-025R
SALSA MLPA Probemix P417 BAP1 – 25 rxn
MLPA
€ 296.00
P417-050R
SALSA MLPA Probemix P417 BAP1 – 50 rxn
MLPA
€ 580.00
P417-100R
SALSA MLPA Probemix P417 BAP1 – 100 rxn
MLPA
€ 1135.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 361.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 361.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6373.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

The commercially available positive samples below can be used with the current (B3) version of this product.

Resources

General MLPA resources

MLPA education

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