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P027 Uveal melanoma

SALSA MLPA Probemix P027 Uveal melanoma detects copy number variations in chromosomes 1p, 3, 6 and 8, which are associated with uveal melanoma.

Specifications

Contents: 50 MLPA probes, including 7 probes for chromosome 1p, 19 probes for chromosome 3, 6 probes for chromosome 6, and 6 probes for chromosome 8.

Tissue: human genomic DNA, including DNA from FFPE tissue.

Application: research on uveal melanoma (UM).

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P016 VHL

Contains at least two probes for each exon of VHL and several flanking probes on 3p25-p26.

P175 Tumour Gain

Contains two probes for MYC gene on 8q24.21.

P417 BAP1

Contains probes for each exon of BAP1 gene on 3p21.1.

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General information

The SALSA MLPA Probemix P027 Uveal melanoma is a research use only (RUO) assay for the detection of deletions or duplications in chromosomes 1p, 3, 6 and 8, which are recurrent genetic alterations in uveal melanoma.

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, with mortality over 50%, usually due to metastatic spread to the liver. Research suggests that UMs with monosomy 3 (50-60% of all UMs) represent a distinct pathological entity as compared to those with normal disomy 3, as monosomy 3 strongly correlates with metastatic potential (Prescher et al. 1996). Chromosome 6 aberrations probably constitute a second entry point in the process of carcinogenesis, while gains in 8q seem to appear later in the natural history of UMs due to their higher frequency in larger tumours. Early detection of high risk UM patients would enable better screening for metastasis and for optimized therapy selection, and as well to reassure patients with no loss of chromosome 3, which is associated with good prognosis (for review see e.g. Jager et al. 2020).

Regulatory status

SALSA MLPA Probemix P027 Uveal melanoma is for research use only (RUO) in all territories.

Product documentation

Version C2

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P027-025R
SALSA MLPA Probemix P027 Uveal melanoma – 25 rxn
MLPA
€ 286.00
P027-050R
SALSA MLPA Probemix P027 Uveal melanoma – 50 rxn
MLPA
€ 560.00
P027-100R
SALSA MLPA Probemix P027 Uveal melanoma – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-Cy5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-Cy5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

See this support article for commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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