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P380 Wilms' tumour

SALSA MLPA Probemix P380 Wilms' tumour detects copy number variations in various genes and regions associated with Wilms' tumour (WT).

Specifications

Contents: 53 MLPA probes, including 7 probes for 1p, 5 probes for 1q, 3 probes for 16p, 6 probes for 16q and 3 probes each for MYCN, FBXW7, WT1, TP53, and AMER1.

Tissue: human genomic DNA, including DNA from FFPE tissue.

Application: research on Wilms' tumour.

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

ME030 BWS/RSS

Contains probes for rapid detection of most causes of BWS/RSS and for screening of Wilms’ tumour.

P056 TP53

Contains probes for all exons of the TP53 gene.

P118 WT1

Contains probes for the WT1 and AMER1 genes involved in Wilms’ tumour, WAGR, Denys-Drash and Frasier syndrome.

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General information

The SALSA MLPA Probemix P380 Wilms' tumour is a research use only (RUO) assay for the detection of deletions or gains on chromosomal arms 1p, 1q, 16p, and 16q. This probemix can further be used to determine the copy number of MYCN on 2p24.3, FBXW7 on 4q31.3, WT1 on 11p13, TP53 on 17p13.1, and AMER1 (previously known as FAM123B) on Xq11.1.

Wilms' tumour (WT) is the most common paediatric renal tumour. Most of the cases occur sporadically in otherwise healthy children. However, a minority of cases is associated with other developmental abnormalities such as WARG, Denys-Drash, Beckwith-Wiedemann, Perlman or Frasier syndrome (Maciaszek et al. 2020). While the survival of children with Wilms' tumour has increased to ~90%, the survival of patients with relapse is still low (~50%) (Spreafico et al. 2021). Copy number changes of certain chromosomal regions and genes have been found to be highly significant for prognosis. Tools to classify these high-risk Wilms' tumour patients are needed to intensify the treatment and, in addition, to reduce the treatment burden of the low-risk patients.

Regulatory status

SALSA MLPA Probemix P380 Wilms' tumour is for research use only (RUO) in all territories.

Product documentation

Version B1

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P380-025R
SALSA MLPA Probemix P380 Wilms' tumour – 25 rxn
MLPA
€ 286.00
P380-050R
SALSA MLPA Probemix P380 Wilms' tumour – 50 rxn
MLPA
€ 560.00
P380-100R
SALSA MLPA Probemix P380 Wilms' tumour – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-Cy5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-Cy5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

See this support article for commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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