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P265 PROC

SALSA MLPA Probemix P265 PROC detects copy number variations in the PROC gene.

Specifications

Contents: 21 MLPA probes, including 10 probes for PROC (covering all exons).

Tissue: human genomic DNA.

Application: research on protein C deficiency.

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P112 PROS1

Contains probes for the PROS1 gene, involved in protein S deficiency, associated with venous thrombosis.

P227 SERPINC1

Contains probes for the SERPINC1 gene, involved in antithrombin (III) deficiency.

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General information

The SALSA MLPA Probemix P265 PROC is a research use only (RUO) assay for the detection of deletions or duplications in the in PROC gene, which is associated with protein C deficiency.

Protein C deficiency is usually inherited as an autosomal dominant trait that is associated with an increased risk of venous thrombosis. A very rare severe homozygous (or compound heterozygous) form of protein C deficiency was first described as a cause of neonatal purpura fulminans, resulting in rapid death caused by disseminated intravascular coagulation (DIC).

Protein C (PROC) is a vitamin K-dependent serine protease zymogen. Purified human activated protein C selectively destroys factors Va and VIII in human plasma and thus has an important anticoagulant role. Regulatory DNA elements responsible for PROC gene expression have been identified in the upstream promoter region and first (untranslated) exon of the PROC gene.

Regulatory status

SALSA MLPA Probemix P265 PROC is for research use only (RUO) in all territories.

Product documentation

Version B4

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P265-025R
SALSA MLPA Probemix P265 PROC – 25 rxn
MLPA
€ 296.00
P265-050R
SALSA MLPA Probemix P265 PROC – 50 rxn
MLPA
€ 580.00
P265-100R
SALSA MLPA Probemix P265 PROC – 100 rxn
MLPA
€ 1135.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 361.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 361.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6373.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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