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P227 SERPINC1

SALSA MLPA Probemix P227 SERPINC1 detects copy number variations in the SERPINC1 gene.

Specifications

Contents: 17 MLPA probes, including 7 probes for SERPINC1 (covering all exons).

Tissue: human genomic DNA.

Application: research on antithrombin deficiency.

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

General information

The SALSA MLPA Probemix P227 SERPINC1 is a research use only (RUO) assay for the detection of deletions or duplications in the SERPINC1 gene, which is associated with antithrombin deficiency.

Antithrombin deficiency is a rare hereditary disorder that generally comes to light when a patient suffers from recurrent venous thrombosis and pulmonary embolism. In renal failure (especially nephrotic syndrome) antithrombin is lost in the urine. This leads to a higher activity of Factor II and Factor X and an increased tendency to thrombosis. Antithrombin (III) deficiency is mainly caused by a defect in the SERPINC1 gene.

The SERPINC1 gene (7 exons) spans ~13.5 kb of genomic DNA, and is located on chromosome 1q25.1, ~173 Mb from the p-telomere.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK284694/.

Regulatory status

SALSA MLPA Probemix P227 SERPINC1 is for research use only (RUO) in all territories.

Product documentation

Version B4

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P227-025R
SALSA MLPA Probemix P227 SERPINC1 – 25 rxn
MLPA
€ 286.00
P227-050R
SALSA MLPA Probemix P227 SERPINC1 – 50 rxn
MLPA
€ 560.00
P227-100R
SALSA MLPA Probemix P227 SERPINC1 – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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