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digitalMLPA Application Highlight

digitalMLPA is paving the way to unparalleled copy number detection by combining the trusted MLPA technology with the power of NGS.

digitalMLPA products are for research use only (RUO).

SALSA digitalMLPA Probemix D001 Hereditary Cancer Panel 1

The digitalMLPA probemix D001 detects CNVs in 28 clinically relevant genes, and detects six specific common (point) mutations. Mutations in these genes are associated with hereditary predisposition to one or more of the following cancer types: breast, ovarian, colorectal, gastric, prostate, pancreatic, endometrial, and melanoma. Read more about the targeted genes on the product page.

Ribbons.
 
Breast
ATM
BRCA1
BRCA2
BARD1
CDH1
CHEK2
NBN
PALB2
PTEN
STK11
TP53
 
Ovarian
BRCA1
BRCA2
BRIP1
EPCAM
MLH1
MSH2
MSH6
PMS2
RAD51C
RAD51D
STK11
TP53
 
Colorectal
APC
BMPR1A
CHEK2
EPCAM
MLH1
MSH2
MSH6
MUTYH
PMS2
POLE
SMAD4
SCG5/GREM1
STK11
TP53
 
Gastric
APC
BMPR1A
CDH1
EPCAM
MLH1
MSH2
MSH6
MUTYH
PMS2
SMAD4
STK11
TP53
 
Prostate
BRCA1
BRCA2
CHEK2
STK11
TP53
 
Pancreatic
BRCA1
BRCA2
CDKN2A
TP53
 
Endometrial
EPCAM
MLH1
MSH2
MSH6
PMS2
PTEN
STK11
TP53
 
Melanoma
BAP1
CDKN2A
CDK4
MITF
TP53

Save time and money on NGS-negative samples

D001 is the perfect time-saving complement to NGS sequencing for high-level CNV calling certainty. digitalMLPA is highly multiplexable, where digitalMLPA reactions and NGS libraries can be run on the same chip. This enables simultaneous CNV quantification and NGS sequence analysis, avoiding extra copy number tests run on NGS-negative samples.

More Information

Read our flyer about SALSA digitalMLPA Probemix D001 Hereditary Cancer Panel 1 or visit the product page.

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