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P475 FOXP1 - FOXP2

SALSA MLPA Probemix P475 FOXP1 - FOXP2 detects copy number variations in the FOXP1 and FOXP2 genes.

Specifications

Contents: 54 MLPA probes, including 26 probes for FOXP1, and 20 probes for FOXP2 (covering all exons of both genes).

Tissue: human genomic DNA.

Application: research on intellectual disability, and speech and language disorder.

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P343 Autism-1

Targets the 15q11-q13 chromosomal region, the 16p11 microdeletion region and the SHANK3 gene at 22q13, involved in autism.

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General information

The SALSA MLPA Probemix P475 FOXP1-FOXP2 is a research use only (RUO) assay for the detection of deletions or duplications in the FOXP1 and FOXP2 genes, which are associated with intellectual disability and speech and language disorder.

Forkhead box (FOX) proteins are a family of transcription factors defined by a forkhead DNA-binding domain, which are involved in a range of functions. Of the FOXP protein subfamily, which includes FOXP1-4, FOXP1 and FOXP2 have been indicated in cognitive disorders (Bacon & Rappold 2012). Mutations in FOXP1 are associated with intellectual disability and may also cause language impairment as well as autistic features (OMIM 613670). FOXP2 mutations are known to cause a severe speech and language disorder (OMIM 602081); autistic features have been reported in some cases.

The FOXP1 gene (21 exons) spans ~629 kb of genomic DNA and is located on 3p14.1, 71 Mb from the p-telomere. The FOXP2 gene (18 exons) spans ~276 kb of genomic DNA and is located on 7q31.1, 114 Mb from the p-telomere.

Regulatory status

SALSA MLPA Probemix P475 FOXP1 - FOXP2 is for research use only (RUO) in all territories.

Product documentation

Version A1

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P475-025R
SALSA MLPA Probemix P475 FOXP1 - FOXP2 – 25 rxn
MLPA
€ 286.00
P475-050R
SALSA MLPA Probemix P475 FOXP1 - FOXP2 – 50 rxn
MLPA
€ 560.00
P475-100R
SALSA MLPA Probemix P475 FOXP1 - FOXP2 – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

The commercially available positive samples below can be used with the current (A1) version of this product.

Resources

General MLPA resources

MLPA education

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