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P441 SACS

SALSA MLPA Probemix P441 SACS detects copy number variations in the SACS gene.

Specifications

Contents: 28 MLPA probes, including 18 probes for SACS.

Tissue: human genomic DNA.

Application: research on autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS).

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P316 Recessive Ataxias

Contains probes for the SETX, APTX, and FXN genes involved in multiple recessive ataxias.

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General information

The SALSA MLPA Probemix P441 SACS is a research use only (RUO) assay for the detection of deletions or duplications in the SACS gene, which is associated with autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS).

ARSACS is a neurodegenerative disorder, characterised by early-onset progressive cerebellar ataxia with spasticity and peripheral neuropathy. The classic form of ARSACS is often displayed in early childhood, leading to delayed walking in young toddlers, while individuals with disease onset in teenage or early-adult years are also being described more recently. ARSACS is caused by mutations in the SACS gene, which encodes the sacsin protein believed to integrate the ubiquitin-proteasome system and Hsp70 chaperone machinery and implicated in the processing of ataxin-1. Sacsin is most highly expressed in large neurons, including cerebellar Purkinje cells.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1255/.

Regulatory status

SALSA MLPA Probemix P441 SACS is for research use only (RUO) in all territories.

Product documentation

Version A2

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P441-025R
SALSA MLPA Probemix P441 SACS – 25 rxn
MLPA
€ 296.00
P441-050R
SALSA MLPA Probemix P441 SACS – 50 rxn
MLPA
€ 580.00
P441-100R
SALSA MLPA Probemix P441 SACS – 100 rxn
MLPA
€ 1135.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 361.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 361.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6373.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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