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P418 MYH7

SALSA MLPA Probemix P418 MYH7 detects copy number variations in the MYH7 gene.

Specifications

Contents: 46 MLPA probes, including 37 probes for MYH7.

Tissue: human genomic DNA.

Application: research on hypertrophic cardiomyopathy (HCM).

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P100 MYBPC3

Contains probes for the MYBPC3 gene, involved in familial HCM.

P168 ARVC-PKP2

Contains probes for the genes DSC2, DSP, JUP, PKP2, RYR2 and TGFB3, involved in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (ARVC).

P196 TNNT2-BAG3

Contains probes for the TNNT2 and BAG3 genes, involved in HCM and Dilated Cardiomyopathy.

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General information

The SALSA MLPA Probemix P418 MYH7 is a research use only (RUO) assay for the detection of deletions or duplications in the MYH7 gene, which is associated with Hypertrophic Cardiomyopathy (HCM).

HCM is characterised by a cardiovascular disease with autosomal dominant inheritance. HCM is caused by defects in the genes coding for structural and/or regulatory proteins found in the sarcomere of cardiomyocytes. In ~20% of HCM patients, mutations in the MYH7 gene on chromosome 14q11 are found. This gene encodes the beta heavy chain subunit of cardiac myosin.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1768/.

Regulatory status

SALSA MLPA Probemix P418 MYH7 is for research use only (RUO) in all territories.

Product documentation

Version B2

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P418-025R
SALSA MLPA Probemix P418 MYH7 – 25 rxn
MLPA
€ 296.00
P418-050R
SALSA MLPA Probemix P418 MYH7 – 50 rxn
MLPA
€ 580.00
P418-100R
SALSA MLPA Probemix P418 MYH7 – 100 rxn
MLPA
€ 1135.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 361.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 361.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6373.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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