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P100 MYBPC3

SALSA MLPA Probemix P100 MYBPC3 detects copy number variations in the MYBPC3 gene.

Specifications

Contents: 43 MLPA probes, including 29 probes for MYBPC3.

Tissue: human genomic DNA.

Application: research on familial hypertrophic cardiomyopathy syndrome.

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P168 ARVC-PKP2

Arrhythmogenic right ventricular cardiomyopathy/dysplasia, genes included: PKP2, DSP, JUP, DSC2, DSG2, TGFB3 and RYR2.

P196 TNNT2-BAG3

Familial Hypertrophic Cardiomyopathy, genes included: TNNT2 and BAG3.

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General information

The SALSA MLPA Probemix P100 MYBPC3 is a research use only (RUO) assay for the detection of deletions or duplications in the MYBPC3 gene, which is associated with familial hypertrophic cardiomyopathy syndrome.

The MYBPC3 gene (35 exons) spans ~21.3 kb of genomic DNA and is located on chromosome 11p11.2. The protein encoded by MYBPC3 is the cardiac isoform of myosin-binding protein C (cMyBP-C), which is exclusively expressed in human heart muscle during development. The cMyBP-C protein is crucial for sarcomere organisation in cardiac muscle tissue and for maintenance of normal cardiac function. Defects in the MYBPC3 gene account for approximately 20-40% of the cases of familial hypertrophic cardiomyopathy.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1768/.

Regulatory status

SALSA MLPA Probemix P100 MYBPC3 is for research use only (RUO) in all territories.

Product documentation

Version C2

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P100-025R
SALSA MLPA Probemix P100 MYBPC3 – 25 rxn
MLPA
€ 296.00
P100-050R
SALSA MLPA Probemix P100 MYBPC3 – 50 rxn
MLPA
€ 580.00
P100-100R
SALSA MLPA Probemix P100 MYBPC3 – 100 rxn
MLPA
€ 1135.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 361.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 361.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6373.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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