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P395 MEF2C-FOXG1

SALSA MLPA Probemix P395 MEF2C-FOXG1 detects copy number variations in the MEF2C and FOXG1 genes.

Specifications

Contents: 42 MLPA probes, including 22 probes for the MEF2C region, and 5 probes for the FOXG1 region.

Tissue: human genomic DNA.

Application: research on disorders related to intellectual disability.

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P015 MECP2

Contains probes for the MECP2 gene and several other genes involved in Rett syndrome.

P036 Subtelomeres Mix 1

Contains a probe for every human subtelomere.

P064 Microdeletion Syndromes-1B

Contains probes for different microdeletion syndromes; can be used for primary screening of microdeletion syndromes.

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General information

The SALSA MLPA Probemix P395 MEF2C-FOXG1 is a research use only (RUO) assay for the detection of deletions or duplications in the MEF2C and FOXG1 genes, which are associated with intellectual disability.

Intellectual disability can be provoked by different chromosomal aberrations, for example deletions of the chromosomal regions 5q14.3 and 14q12. Deletions of the 5q14.3 region mainly affect the MEF2C gene encoding myocyte enhancer factor 2C. It was shown that microdeletions in this gene are involved in severe intellectual disability, stereotypic movements, epilepsy, and/or cerebral malformation (Zweier 2010; Le Meur 2010; Nowakowska 2010). Another gene that has been implicated in intellectual disability is the FOXG1 gene encoding forkhead box G1. Copy number variants (Mencarelli 2009; Kortüm 2011; OMIM #613454), as well as point mutations (Bahi-Buisson 2010; Allou 2012) have been described in literature as a potential cause of a Rett-like phenotype.

More information on MEF2C is available at https://www.omim.org/entry/600662

More information on FOXG1 is available at https://www.omim.org/entry/164874

Regulatory status

SALSA MLPA Probemix P395 MEF2C-FOXG1 is for research use only (RUO) in all territories.

Product documentation

Version B1

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P395-025R
SALSA MLPA Probemix P395 MEF2C-FOXG1 – 25 rxn
MLPA
€ 296.00
P395-050R
SALSA MLPA Probemix P395 MEF2C-FOXG1 – 50 rxn
MLPA
€ 580.00
P395-100R
SALSA MLPA Probemix P395 MEF2C-FOXG1 – 100 rxn
MLPA
€ 1135.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 361.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 361.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6373.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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