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P381 COL11A1 mix 1

SALSA MLPA probemixes P381 COL11A1 mix 1 and P382 COL11A1 mix 2 detect copy number variations in the COL11A1 gene.

Specifications

Contents: P381 COL11A1 mix 1 and P382 COL11A1 mix 2 together contain 76 MLPA probes, including 56 probes for COL11A1.

Tissue: human genomic DNA.

Application: research on Marshall syndrome, and type II Stickler syndrome.

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P214 COL2A1

Contains probes for COL2A1, involved in Stickler syndrome type I.

P382 COL11A1 mix 2

Probes for COL11A1, involved in type 2 Stickler syndrome and Marshall syndrome.

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General information

The SALSA MLPA Probemixes P381 COL11A1 mix 1 and P382 COL11A1 mix 2 are research use only (RUO) assays for the detection of deletions or duplications in the COL11A1 gene, which is associated with Marshall and type II Stickler syndromes.

Marshall syndrome is an autosomal dominant inherited disease characterised by short stature, nearsightedness, hearing loss, and intracranial ossifications. Type II Stickler syndrome patients have similar symptoms but are of near normal height and exhibit no bony overgrowths. Both syndromes occasionally present with cleft palate and patients frequently develop early osteoarthritis (Kahler et al. 2008). Since the characteristics of these syndromes overlap, it has been argued whether they are distinct entities or different manifestations of a single syndrome. Defects in COL11A1 gene cause Marshall and type II Stickler syndromes.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1302/.

Regulatory status

SALSA MLPA Probemix P381 COL11A1 mix 1 is for research use only (RUO) in all territories.

Product documentation

Version A4

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P381-025R
SALSA MLPA Probemix P381 COL11A1 mix 1 – 25 rxn
MLPA
€ 296.00
P381-050R
SALSA MLPA Probemix P381 COL11A1 mix 1 – 50 rxn
MLPA
€ 580.00
P381-100R
SALSA MLPA Probemix P381 COL11A1 mix 1 – 100 rxn
MLPA
€ 1135.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 361.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 361.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6373.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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