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P334 Gonadal

SALSA MLPA Probemix P334 Gonadal detects copy number variations in the DMRT1, CYP17A1, SRD5A2 and HSD17B3 genes.

Specifications

Contents: 35 MLPA probes including 10 probes for DMRT1 (covering all exons), 7 probes for CYP17A1, 7 probes for SRD5A2 (covering all exons), and 3 probes for HSD17B3.

Tissue: human genomic DNA.

Application: research on gonadal development disorders.

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P185 Intersex

Contains probes for the NR0B1, NR5A1, SOX9 and WNT4 genes.

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General information

The SALSA MLPA Probemix P334 Gonadal is a research use only (RUO) assay for the detection of deletions or duplications in the DMRT1, CYP17A1, SRD5A2 and HSD17B3 genes, which are associated with gonadal development disorders.

The development and function of the mammalian gonad is influenced by several pathways. In the current SALSA MLPA P334 probemix, four genes (DMRT1, CYP17A1, SRD5A2 and HSD17B3) have been included which are all known to have an effect on gonadogenesis. The effects of mutations or loss of function of these genes range from pseudohermaphroditism, synthesis of androgens and oestrogens to gonadal dysgenesis.

The DMRT1 gene (5 exons), spans ~127 kb of genomic DNA and is located on chromosome 9p24.3, 0.8 Mb from the p-telomere. The CYP17A1 gene (8 exons), spans ~7 kb of genomic DNA and is located on chromosome 10q24.32, 105 Mb from p-telomere. The SRD5A2 gene (5 exons), spans ~56 kb of genomic DNA and is located on chromosome 2p23.1, 32 Mb from p-telomere. The HSD17B3 gene (11 exons), spans ~67 kb of genomic DNA and is located on chromosome 9q22.32, 98 Mb from the p-telomere.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1547/.

Regulatory status

SALSA MLPA Probemix P334 Gonadal is for research use only (RUO) in all territories.

Product documentation

Version A5

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P334-025R
SALSA MLPA Probemix P334 Gonadal – 25 rxn
MLPA
€ 286.00
P334-050R
SALSA MLPA Probemix P334 Gonadal – 50 rxn
MLPA
€ 560.00
P334-100R
SALSA MLPA Probemix P334 Gonadal – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

See this support article for commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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