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P272 COL1A2

SALSA MLPA Probemix P272 COL1A2 detects copy number variations in the COL1A2 gene.

Specifications

Contents: 43 MLPA probes, including 35 probes for COL1A2.

Tissue: human genomic DNA.

Application: research on osteogenesis imperfecta (OI).

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P271 COL1A1

Targets COL2A1, also involved in osteogenesis imperfecta (OI).

View all

General information

The SALSA MLPA Probemix P272 COL1A2 is a research use only (RUO) assay for the detection of deletions or duplications in the COL1A2 gene, which is associated with Osteogenesis Imperfecta (OI).

Type I collagen is the most common type of collagen. It is present in almost all connective tissues. This protein consists of three polypeptide chains: two alpha-1 polypeptide chains and one alpha-2 polypeptide chain, which are encoded by the COL1A1 gene and the COL1A2 gene, respectively.

OI is a genetic disorder characterised by bone fragility, severe bowing of long bones and low bone mass. The prevalence of this disorder ranges from one per 10,000 to one per 20,000 live births. Severe forms of OI lead to intrauterine fractures and perinatal lethality. Besides bone, other tissues rich in type I collagen are also affected, including skin, ligaments, and tendons. About 90% of the patients diagnosed with OI have mutations in the COL1A1 or COL1A2 genes.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1295/.

Regulatory status

SALSA MLPA Probemix P272 COL1A2 is for research use only (RUO) in all territories.

Product documentation

Version C1

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P272-025R
SALSA MLPA Probemix P272 COL1A2 – 25 rxn
MLPA
€ 286.00
P272-050R
SALSA MLPA Probemix P272 COL1A2 – 50 rxn
MLPA
€ 560.00
P272-100R
SALSA MLPA Probemix P272 COL1A2 – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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