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P271 COL1A1

SALSA MLPA Probemix P271 COL1A1 detects copy number variations in the COL1A1 gene.

Specifications

Contents: 42 MLPA probes, including 33 probes for COL1A1.

Tissue: human genomic DNA.

Application: research on osteogenesis imperfecta (OI).

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P272 COL1A2

Targets COL2A2, also involved in osteogenesis imperfecta (OI).

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General information

The SALSA MLPA Probemix P271 COL1A1 is a research use only (RUO) assay for the detection of deletions or duplications in the COL1A1 gene, which is associated with osteogenesis imperfecta (OI).

OI is a genetic disorder characterized by bone fragility, severe bowing of long bones, and low bone mass. The prevalence of this disorder ranges from one per 10,000 to one per 20,000 live births. Severe forms of OI lead to intrauterine fractures and perinatal lethality. Besides bone, other tissues rich in type I collagen are also affected, including skin, ligaments, and tendons. The majority of patients diagnosed with OI have mutations in the COL1A1 or COL1A2 genes.

Type I collagen is the most common type of collagen and it is present in almost all connective tissues. This protein consists of three polypeptide chains: two ɑ1 polypeptide chains and one ɑ2 polypeptide chain. The ɑ1 polypeptide is encoded by the COL1A1 gene and the ɑ2 polypeptide by the COL1A2 gene.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1295/.

Regulatory status

SALSA MLPA Probemix P271 COL1A1 is for research use only (RUO) in all territories.

Product documentation

Version B5

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P271-025R
SALSA MLPA Probemix P271 COL1A1 – 25 rxn
MLPA
€ 286.00
P271-050R
SALSA MLPA Probemix P271 COL1A1 – 50 rxn
MLPA
€ 560.00
P271-100R
SALSA MLPA Probemix P271 COL1A1 – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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