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SALSA MLPA Probemix P132 Kallmann-1

Kallmann syndrome, X-linked

Region: ANOS1 Xp22.31

General Information: The SALSA MLPA Probemix P132 Kallmann-1 is a research use only (RUO) assay for the detection of deletions or duplications in the ANOS1 (KAL1) gene, which is associated with Kallmann syndrome.

Kallmann syndrome is a distinct form of Isolated Gonadotropin-Releasing Hormone (GnRH) deficiency characterised by anosmia or hyposmia. ANOS1 encodes the extracellular matrix protein, anosmin-1, that plays a key role in the migration of GnRH neurons and olfactory nerves to the hypothalamus.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1334/

This SALSA MLPA Probemix is not CE/FDA registered for use in diagnostic procedures. Purchase of this product includes a limited license for research purposes.

Probemix content: The SALSA MLPA Probemix P132-A3 Kallmann-1 contains 32 MLPA probes with amplification products between 136 and 400 nucleotides (nt). This includes 16 probes for the ANOS1 gene and four flanking probes that detect locations on both sides of the ANOS1 gene. In addition, 12 reference probes are included that detect locations on the X-chromosome. Complete probe sequences and the identity of the genes detected by the reference probes are available online (www.mlpa.com).

This Probemix contains ten quality control fragments generating amplification products between 64 and 121 nt: four DNA Quantity Fragments (Q-fragments), two DNA Denaturation Fragments (D-fragments), one benchmark fragment, and one chromosome X and two chromosome Y-specific fragment. More information on how to interpret observations on these control fragments can be found in the MLPA General Protocol and online at www.mlpa.com.

Order Items

Probemix

Item no.
Description
Technology
Price
P132-025R
SALSA MLPA Probemix P132 Kallmann-1 – 25 rxn
€ 243.00
P132-050R
SALSA MLPA Probemix P132 Kallmann-1 – 50 rxn
€ 486.00
P132-100R
SALSA MLPA Probemix P132 Kallmann-1 – 100 rxn
€ 972.00

Required Reagents

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA EK1 reagent kit – 100 rxn – FAM
€ 300.00
EK1-Cy5
SALSA MLPA EK1 reagent kit – 100 rxn – Cy5
€ 300.00
EK5-FAM
SALSA MLPA EK5 reagent kit – 500 rxn – FAM
€ 1380.00
EK5-Cy5
SALSA MLPA EK5 reagent kit – 500 rxn – Cy5
€ 1380.00
EK20-FAM
SALSA MLPA EK20 reagent kit – 2000 rxn – FAM
€ 5295.00

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SALSA MLPA Probemix P160 STS

Contains probes for the STS gene.

SALSA MLPA Probemix P201 CHARGE

Contains probes for the CHD7 gene, involved in CHARGE syndrome.

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