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P389 MLL2

SALSA MLPA Probemix P389 MLL2 detects copy number variations in the MLL2 gene.

Specifications

Contents: 35 MLPA probes, including 26 probes for MLL2.

Tissue type: human genomic DNA.

Application: research on Kabuki syndrome (KS).

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P445 KDM6A

Contains probes for the KDM6A gene, involved in Kabuki syndrome type 2.

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General information

The SALSA MLPA Probemix P389 MLL2 is a research use only (RUO) assay for the detection of deletions or duplications in the MLL2 gene, which is associated with Kabuki Syndrome (KS).

KS is a rare syndrome characterised by intellectual disability and multiple congenital abnormalities, in particular a distinct dysmorphic facial appearance. KS can be caused by mutations in the MLL2 gene (also known as KMT2D), encoding an H3K4 histone methyl transferase which acts as an epigenetic transcriptional activator during growth and development. The vast majority of reported cases have been sporadic, but parent-to-child transmission suggests that KS is an autosomal dominant disorder.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK62111/.

Regulatory status

SALSA MLPA Probemix P389 MLL2 is for research use only (RUO) in all territories.

Product documentation

Version B1

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P389-025R
SALSA MLPA Probemix P389 MLL2 – 25 rxn
MLPA
€ 296.00
P389-050R
SALSA MLPA Probemix P389 MLL2 – 50 rxn
MLPA
€ 580.00
P389-100R
SALSA MLPA Probemix P389 MLL2 – 100 rxn
MLPA
€ 1135.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 361.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 361.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6373.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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