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P385 DOCK8

SALSA MLPA probemixes P385 DOCK8 and P386 DOCK8-STAT3 detect copy number variations in the DOCK8 and STAT3 genes.

Specifications

Contents: P385 DOCK8 and P386 DOCK8-STAT3 together contain 94 MLPA probes, including 51 probes for DOCK8, and 24 probes for STAT3.

Tissue type: human genomic DNA.

Application: research on hyper-IgE syndrome.

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P386 SALSA MLPA P386 DOCK8-STAT3 probemix

Hyper IgE syndrome, autosomal recessive (AR-HIES); Hyper IgE syndrome, autosomal dominant (AD-HIES). Contains probes for all DOCK8 exons when used together with P385 and contains probes for STAT3.

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General information

The SALSA MLPA Probemixes P385 DOCK8 and P386 DOCK8-STAT3 are research use only (RUO) assays for the detection of deletions or duplications in the DOCK8 and STAT3 genes, which are associated with Hyper-IgE syndrome.

Hyper-IgE syndrome (HIES) is a rare immunodeficiency disease, often accompanied by high serum IgE. It is often characterized by facial features, repeated skin infections, eczema and pulmonary infection, including autosomal dominant HIES (AD-HIES) and autosomal recessive HIES (AR-HIES). AD-HIES is caused by mutations in the STAT3 gene. AR-HIES is mainly caused by mutations in the DOCK8 gene.

The DOCK8 gene (48 exons) spans ~192 kb of genomic DNA and is located on chromosome 9p24.3, 0.2 Mb from the p-telomere. The STAT3 gene (24 exons) spans ~75 kb of genomic DNA and is located on chromosome 17q21.2, 38 Mb from the p-telomere.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK25507/.

Regulatory status

SALSA MLPA Probemix P385 DOCK8 is for research use only (RUO) in all territories.

Product documentation

Version A3

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P385-025R
SALSA MLPA Probemix P385 DOCK8 – 25 rxn
MLPA
€ 296.00
P385-050R
SALSA MLPA Probemix P385 DOCK8 – 50 rxn
MLPA
€ 580.00
P385-100R
SALSA MLPA Probemix P385 DOCK8 – 100 rxn
MLPA
€ 1135.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 361.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 361.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6373.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

The commercially available positive samples below can be used with the current (A3) version of this product.

Resources

General MLPA resources

MLPA education

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