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P307 SEPT9

SALSA MLPA Probemix P307 SEPT9 detects copy number variations in the SEPT9 gene.

Specifications

Contents: 29 MLPA probes, including 19 probes for the SEPT9 region.

Tissue: human genomic DNA.

Application: research on hereditary neuralgic amyopathy (HNA).

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P033 CMT1

Contains probes for the PMP22 gene (linked to HNPP).

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General information

The SALSA MLPA Probemix P307 SEPT9 is a research use only (RUO) assay for the detection of deletions or duplications in the SEPT9 gene, which is associated with Hereditary Neuralgic Amyopathy (HNA).

HNA is an autosomal dominant disorder that affects the brachial plexus and may first appear in childhood. It is characterized by episodes of sudden onset pain in arms and shoulders as well as weakness, followed by total or partial paralysis of the affected area. These episodes are often triggered by an infection, an immunization, childbirth, or overworking the arms and shoulders.

HNA has been associated with mutations in the SEPT9 gene encoding Septin 9, a member of the Septin family. Septins are a group of evolutionarily conserved genes encoding proteins with various functions, including membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis, and oncogenesis. Septin 9 is ubiquitously expressed and it is believed that it is involved in cytokinesis and tumorigenesis.

Regulatory status

SALSA MLPA Probemix P307 SEPT9 is for research use only (RUO) in all territories.

Product documentation

Version B4

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P307-025R
SALSA MLPA Probemix P307 SEPT9 – 25 rxn
MLPA
€ 296.00
P307-050R
SALSA MLPA Probemix P307 SEPT9 – 50 rxn
MLPA
€ 580.00
P307-100R
SALSA MLPA Probemix P307 SEPT9 – 100 rxn
MLPA
€ 1135.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 361.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 361.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1658.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6373.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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