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P234 GATA3 - GATA4

SALSA MLPA Probemix P234 GATA3 - GATA4 detects copy number variations in the GATA3 and GATA4 genes.

Specifications

Contents: 28 MLPA probes, including 5 probes for GATA3 (covering all exons), and 10 probes for the GATA4 region.

Tissue: human genomic DNA.

Application: research on cardiac septal defects, and HDR dysplasia syndrome.

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P250 DiGeorge

Contains probes for the 22q11 DiGeorge region.

P311 Congenital Heart Disease

Contains more probes for congenital heart disease.

View all

General information

The SALSA MLPA Probemix P234 GATA3 - GATA4 is a research use only (RUO) assay for the detection of deletions or duplications in the GATA3 and GATA4 genes.

The GATA4 gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognise the GATA motif, which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in the GATA4 gene have been associated with cardiac septal defects (OMIM#600576).

Microdeletions of chromosome 10p14, affecting among others the GATA3 gene, result in a DiGeorge-like phenotype that includes hypoparathyroidism, heart defects, immune deficiency, deafness, and renal malformations. One region that contributes to this complex phenotype is that for the syndrome of hypoparathyroidism, sensorineural deafness, and renal insufficiency (HDR). The HDR dysplasia syndrome is an autosomal dominant disorder caused by mutations or intragenic deletions of the dual zinc finger transcription factor, GATA3 (OMIM#131320).

Regulatory status

SALSA MLPA Probemix P234 GATA3 - GATA4 is for research use only (RUO) in all territories.

Product documentation

Version A4

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P234-025R
SALSA MLPA Probemix P234 GATA3 - GATA4 – 25 rxn
MLPA
€ 286.00
P234-050R
SALSA MLPA Probemix P234 GATA3 - GATA4 – 50 rxn
MLPA
€ 560.00
P234-100R
SALSA MLPA Probemix P234 GATA3 - GATA4 – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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