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P170 APP

SALSA MLPA Probemix P170 APP detects copy number variations in the APP gene.

Specifications

Contents: 38 MLPA probes, including 21 probes for APP (covering all exons).

Tissue: human genomic DNA.

Application: research on early-onset Alzheimer's disease (EOAD) and cerebral amyloid angiopathy (CAA).

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P254 PSEN1

Alzheimer's disease (AD) - genes included: PSEN1.

P275 MAPT-GRN

Alzheimer's disease (AD) - genes included: MAPT.

View all

General information

The SALSA MLPA Probemix P170 APP is a research use only (RUO) assay for the detection of deletions or duplications in the APP gene, which is associated with Early-Onset Alzheimer's Disease (EOAD) and Cerebral Amyloid Angiopathy (CAA).

Duplications in the APP gene result in accumulation of amyloid-β peptides in the parenchymal and vascular deposits and have been implicated in EOAD and CAA. The size of duplications can vary among patients, ranging from 0.58 to 6.37 Mb.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1161/.

Regulatory status

SALSA MLPA Probemix P170 APP is for research use only (RUO) in all territories.

Product documentation

Version C3

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P170-025R
SALSA MLPA Probemix P170 APP – 25 rxn
MLPA
€ 286.00
P170-050R
SALSA MLPA Probemix P170 APP – 50 rxn
MLPA
€ 560.00
P170-100R
SALSA MLPA Probemix P170 APP – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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