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P459 SERPINA1

SALSA MLPA Probemix P459 SERPINA1 detects copy number variations in the SERPINA1 gene.

Specifications

Contents: 21 MLPA probes, including 9 probes for SERPINA1 (covering all exons).

Tissue: human genomic DNA.

Application: research on alpha-1 antitrypsin deficiency (AATD).

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

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General information

The SALSA MLPA Probemix P459 SERPINA1 is a research use only (RUO) assay for the detection of deletions or duplications in the SERPINA1 gene, which is associated with Alpha-1 antitrypsin deficiency (AATD).

AATD is an autosomal recessive disorder and is characterised by an increased risk for chronic obstructive pulmonary disease (COPD) in adults and liver disease in children and adults which, amongst others, may result in cirrhosis and panniculitis. Defects in the SERPINA1 gene on chromosome 14 are the main cause of AATD. The protein encoded by this gene is alpha-1-antitrypsin (AAT), also known as protease inhibitor (PI). The most important role of AAT is inhibiting neutrophil elastase, a protease that degrades elastin in the alveolar walls as well as other structural proteins in a variety of tissues. Defects in the SERPINA1 gene can lead to tissue damage due to uncontrolled elastase activity.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1519/.

Regulatory status

SALSA MLPA Probemix P459 SERPINA1 is for research use only (RUO) in all territories.

Product documentation

Version A2

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P459-025R
SALSA MLPA Probemix P459 SERPINA1 – 25 rxn
MLPA
€ 286.00
P459-050R
SALSA MLPA Probemix P459 SERPINA1 – 50 rxn
MLPA
€ 560.00
P459-100R
SALSA MLPA Probemix P459 SERPINA1 – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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