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P295 SPRED1

SALSA MLPA Probemix P295 SPRED1 detects copy number variations in the SPRED1 gene.

Specifications

Contents: 38 MLPA probes, including 23 probes for the SPRED1 region (covering all exons).

Tissue: human genomic DNA.

Application: research on Legius syndrome (also known as neurofibromatosis type 1-like syndrome; NFLS).

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

Key related products

P044 NF2

Contains probes for the NF2 gene, involved in Neurofibromatosis type 2.

P081 NF1 mix 1

Contains probes for the NF1 gene, involved in Neurofibromatosis type 1.

P082 NF1 mix 2

Contains probes for the NF1 gene, involved in Neurofibromatosis type 1.

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General information

The SALSA MLPA Probemix P295 SPRED1 is a research use only (RUO) assay for the detection of deletions or duplications in the SPRED1 gene, which are associated with Legius syndrome.

Legius syndrome (also known as Neurofibromatosis Type 1-like syndrome; NFLS) is characterised by multiple café-au-lait spots. Other features may include an abnormally large head (macrocephaly) and unusual facial characteristics. The syndrome has many symptomatic similarities with Neurofibromatosis Type I (NF1). SPRED1 (Sprouty-related EVH1 domain containing 1) is a member of the Sprouty family of proteins that regulate growth factor-induced activation of the Ras/MAP kinase cascade. Mutations in the SPRED1 gene cause Legius syndrome.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK47312/

Regulatory status

SALSA MLPA Probemix P295 SPRED1 is for research use only (RUO) in all territories.

Product documentation

Version B3

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P295-025R
SALSA MLPA Probemix P295 SPRED1 – 25 rxn
MLPA
€ 286.00
P295-050R
SALSA MLPA Probemix P295 SPRED1 – 50 rxn
MLPA
€ 560.00
P295-100R
SALSA MLPA Probemix P295 SPRED1 – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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