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P177 CASR

SALSA MLPA Probemix P177 CASR detects copy number variations in the CASR gene.

Specifications

Contents: 23 MLPA probes, including 14 probes for CASR (covering all exons).

Tissue: human genomic DNA.

Application: research on familial hypocalciuric hypercalcemia (FHH).

For research use only (RUO). Not for use in diagnostics.

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List Prices Documentation

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General information

The SALSA MLPA Probemix P177-B3 CASR is a research use only (RUO) assay for the detection of deletions or duplications in the CASR gene.

Familial Hypocalciuric Hypercalcemia (FHH) is characterized by high levels of calcium in the blood and low levels of calcium in the urine. FHH is primarily caused by inactivating mutations in the CASR gene, while activating mutations cause Automosomal Dominant Hypocalcemia that is characterized by low levels of calcium in the blood. The protein encoded by the CASR gene is a G protein-coupled receptor expressed in cells of the parathyroid gland and the kidney. This protein senses small changes in circulating calcium concentrations to help maintaining a stable calcium concentration.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1116.

Regulatory status

SALSA MLPA Probemix P177 CASR is for research use only (RUO) in all territories.

Product documentation

Version B3

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P177-025R
SALSA MLPA Probemix P177 CASR – 25 rxn
MLPA
€ 286.00
P177-050R
SALSA MLPA Probemix P177 CASR – 50 rxn
MLPA
€ 560.00
P177-100R
SALSA MLPA Probemix P177 CASR – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

We have no information about specific commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

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